INT23188

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Context Info
Confidence 0.79
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 16.06
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
neurons 4
endothelial cells 2
astrocytes 2
adipose tissue 2
vascular endothelium 1
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 54 98.24 Very High Very High Very High
agonist 46 96.88 Very High Very High Very High
Inflammation 209 95.12 Very High Very High Very High
Bioavailability 7 94.08 High High
cytokine 33 92.04 High High
Angina 13 82.72 Quite High
bradykinin 7 78.48 Quite High
Inflammatory marker 9 73.36 Quite High
ischemia 35 70.64 Quite High
cva 12 69.60 Quite High
Disease Link Frequency Relevance Heat
Sepsis 50 99.92 Very High Very High Very High
Disorder Of Lipid Metabolism 458 99.76 Very High Very High Very High
Obesity 25 99.76 Very High Very High Very High
Stroke 162 99.56 Very High Very High Very High
Hyperlipidemia 33 99.38 Very High Very High Very High
Adhesions 88 99.32 Very High Very High Very High
Metabolic Syndrome 134 99.16 Very High Very High Very High
Cardiovascular Disease 33 99.08 Very High Very High Very High
Insulin Resistance 104 99.00 Very High Very High Very High
Prediabetic State 72 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Early after stroke, reactive astrocytes secrete abundant factors, such as tPA as well as PAI-1 [24], [81]–[83].
Localization (secrete) of PAI in astrocytes associated with stroke
1) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.52 Pain Relevance 0
With specific inhibitors, i.e., plasminogen activator inhibitor (PAI)-1 (encoded by serpine 1 gene, secreted by neurons and active astrocytes) and neuroserpin (encoded by serpini 1 gene, secreted by neurons) [12]–[14], the activity of the PA/plasmin system is in equilibrium in the mammalian brain.
Localization (secreted) of serpine 1 in neurons
2) Confidence 0.79 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.24 Pain Relevance 0.13
The concomitant MSC induced reduction of PAI-1 and increase of tPA in astrocytes of the IBZ thereby amplify tPA activity which contributes to neurite outgrowth.
Localization (reduction) of PAI in astrocytes
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.72 Pain Relevance 0.15
With specific inhibitors, i.e., plasminogen activator inhibitor (PAI)-1 (encoded by serpine 1 gene, secreted by neurons and active astrocytes) and neuroserpin (encoded by serpini 1 gene, secreted by neurons) [12]–[14], the activity of the PA/plasmin system is in equilibrium in the mammalian brain.
Localization (secreted) of PAI in neurons
4) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.24 Pain Relevance 0.13
With specific inhibitors, i.e., plasminogen activator inhibitor (PAI)-1 (encoded by serpine 1 gene, secreted by neurons and active astrocytes) and neuroserpin (encoded by serpini 1 gene, secreted by neurons) [12]–[14], the activity of the PA/plasmin system is in equilibrium in the mammalian brain.
Localization (secreted) of PAI in neurons
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.24 Pain Relevance 0.14
With specific inhibitors, i.e., plasminogen activator inhibitor (PAI)-1 (encoded by serpine 1 gene, secreted by neurons and active astrocytes) and neuroserpin (encoded by serpini 1 gene, secreted by neurons) [12]–[14], the activity of the PA/plasmin system is in equilibrium in the mammalian brain.
Localization (secreted) of plasminogen activator inhibitor in neurons
6) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.25 Pain Relevance 0.14
Recently, it has been recognized that endothelial cells play a pivotal role in the pathogenesis of sepsis by releasing tissue factor thrombomodulin and PAI-1 [2].
Localization (releasing) of PAI in endothelial cells associated with sepsis
7) Confidence 0.67 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 1.09 Pain Relevance 0
Immunohistochemical analysis of P-selectin and PAI-1 expression
Localization (analysis) of PAI
8) Confidence 0.63 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.12 Pain Relevance 0
appears to have antifibrotic effects correlated with PAI-1, and TGF-?
Localization (correlated) of PAI-1
9) Confidence 0.50 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.29 Pain Relevance 0.27
Therefore, the PAI-1 aptamer SM-20 demonstrates therapeutic potential as an antimetastatic agent and could possibly be used as an adjuvant to traditional chemotherapy for breast cancer.
Localization (used) of PAI-1 associated with breast cancer
10) Confidence 0.44 Published 2009 Journal Oligonucleotides Section Abstract Doc Link 19284310 Disease Relevance 0.55 Pain Relevance 0.06
85 years had 1.6-fold and 1.5-fold increases in D-dimer and TAT, respectively, and had 1.4-fold, 1.0-fold, and 1.2-fold decreases in PAI-1, AT, and F-IX, respectively.
Localization (decreases) of PAI-1
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.13 Pain Relevance 0.04
This correlation may reflect the in vitro inhibitory effect of HDL on tPA and PAI secretion by the endothelium (Ren and Shen 2000).
Localization (secretion) of PAI in endothelium associated with disorder of lipid metabolism
12) Confidence 0.36 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.22 Pain Relevance 0.03
Hypercholesterolemia and hypertriglyceridemia are associated with increased secretion of PAI-1 from endothelial cells (Stiko-Rahm et al 1990; Norata, Pirillo, et al 2003).
Localization (secretion) of PAI in endothelial cells associated with hyperlipidemia
13) Confidence 0.36 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.16 Pain Relevance 0
Modulation of hemostasis includes the release of plasminogen activator, tissue factor inhibitor, von Willebrand factor, NO, prostacyclin, TXA2, plasminogen-activator inhibitor-1 (PAI-1), and fibrinogen.
Localization (release) of plasminogen-activator inhibitor-1
14) Confidence 0.34 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.97 Pain Relevance 0.13
Indeed, adipose tissue is able to secrete a number of “adipokines” [17] some of them, like resistin, leptin, adiponectin, Monocyte Chemoattractant Protein-1, Interleukin-6, angiotensinogen, angiotensin-converting enzyme, plasminogen activator inhibitor-1 (PAI-1), being implicated in cardiovascular disease [rev. in 18, 19].
Localization (secrete) of PAI-1 in adipose tissue associated with cardiovascular disease and obesity
15) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 1.27 Pain Relevance 0
In endothelial cells, CRP facilitated the release of PAI-1 (Devaraj et al 2003) and endothelin-1 (Verma et al 2002), and increased the expression of cell adhesion molecules (Pasceri et al 2000), reduced NO bioavailability (Venugopal et al 2002), and NO-mediated dilation in the vasculature.
Localization (release) of PAI-1 in vasculature associated with adhesions and bioavailability
16) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350124 Disease Relevance 0.26 Pain Relevance 0.09
Indeed, adipose tissue is able to secrete a number of “adipokines” [17] some of them, like resistin, leptin, adiponectin, Monocyte Chemoattractant Protein-1, Interleukin-6, angiotensinogen, angiotensin-converting enzyme, plasminogen activator inhibitor-1 (PAI-1), being implicated in cardiovascular disease [rev. in 18, 19].
Localization (secrete) of activator inhibitor-1 in adipose tissue associated with cardiovascular disease and obesity
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2936567 Disease Relevance 1.27 Pain Relevance 0
TSP1 is involved in the formation and resolution of a fibrin clot and binds to many proteins and proteases.(16) TSP1 interacts with heparan sulfates, proteoglycans, integrins, fibrinogen and fibronectin.(18) It also binds to components of the fibrinolytic system (plasminogen, urokinase and its inhibitor PAI-1)(19,20) and to cathepsin G and elastase.(21)
Localization (urokinase) of PAI-1
18) Confidence 0.13 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.26 Pain Relevance 0.06
Elevations in plasminogen activator inhibitor-1 (PAI-1) are present in the MS, IR, PD, and T2DM patient.
Localization (Elevations) of PAI-1 associated with diabetes mellitus, prediabetic state, metabolic syndrome and insulin resistance
19) Confidence 0.10 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.76 Pain Relevance 0.03
Elevations in plasminogen activator inhibitor-1 (PAI-1) are present in the MS, IR, PD, and T2DM patient.
Localization (Elevations) of plasminogen activator inhibitor-1 associated with diabetes mellitus, prediabetic state, metabolic syndrome and insulin resistance
20) Confidence 0.10 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.76 Pain Relevance 0.03

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