INT231888

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.43
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
ventricle 2
muscle 2
abdomen 2
lung 1
respiratory 1
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 3 99.48 Very High Very High Very High
anesthesia 9 81.84 Quite High
cva 2 42.72 Quite Low
noradrenaline 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 23 93.92 High High
Pressure And Volume Under Development 14 93.44 High High
Cirrhosis 29 92.32 High High
Renal Failure 15 91.44 High High
Cv General 2 Under Development 1 76.52 Quite High
Adult Respiratory Distress Syndrome 6 75.48 Quite High
Sepsis 3 75.28 Quite High
Compartment Syndromes 24 73.04 Quite High
Peritonitis 2 70.32 Quite High
Necrosis 1 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increases in IAP are also associated with increased respiratory pressures, and decreased lung compliance and gas exchange [41,42].
Negative_regulation (decreased) of in lung Positive_regulation (Increases) of IAP in respiratory
1) Confidence 0.42 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.31 Pain Relevance 0
We hypothesized that increased IAP decreases during PEEP release, and that this effect is more pronounced in the upper abdomen and intra-vascularly.


Negative_regulation (decreases) of Positive_regulation (increased) of IAP in abdomen
2) Confidence 0.42 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.07 Pain Relevance 0.13
It has been shown that bolus administration of opioids and muscle relaxants can increase and decrease, respectively, IAP [47,48].
Negative_regulation (decrease) of Positive_regulation (increase) of IAP in muscle associated with opioid
3) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.05 Pain Relevance 0.10
In addition an increase in IAP could decrease venous return to the right ventricle or impair right-ventricular diastolic filling, thus aggravating the hyperdynamic circulatory dysfunction by adding a hypovolaemic or obstructive component.
Negative_regulation (decrease) of Positive_regulation (increase) of IAP in ventricle
4) Confidence 0.22 Published 2008 Journal Crit Care Section Body Doc Link PMC2374626 Disease Relevance 1.99 Pain Relevance 0

General Comments

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