INT23191

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Context Info
Confidence 0.60
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 14.39
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 2
blood 1
NK cell 1
LAK cell 1
HDLCQ1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 5 98.44 Very High Very High Very High
Angina 29 97.20 Very High Very High Very High
Inflammation 26 90.32 High High
fluoxetine 6 83.04 Quite High
Inflammatory marker 5 71.16 Quite High
depression 6 59.20 Quite High
Pain 8 5.00 Very Low Very Low Very Low
alcohol 7 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 240 100.00 Very High Very High Very High
Cardiovascular Disease 57 100.00 Very High Very High Very High
Hypertension 18 99.88 Very High Very High Very High
Allergic Dermatitis 3 99.84 Very High Very High Very High
Coronary Artery Disease 134 99.80 Very High Very High Very High
Hyperglycemia 1 99.60 Very High Very High Very High
Hyperlipidemia 21 99.08 Very High Very High Very High
Congenital Anomalies 2 98.72 Very High Very High Very High
Stress 31 98.68 Very High Very High Very High
Pressure And Volume Under Development 2 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nearly 1:1 segregation ratio for the group of offspring was not due to the aggregation of sibships with, in general, most of the sibs, or none of the sibs affected; within-family expression of low HDLC was also not sex-linked.
Gene_expression (expression) of HDLC
1) Confidence 0.60 Published 1984 Journal Metab. Clin. Exp. Section Abstract Doc Link 6694557 Disease Relevance 0.54 Pain Relevance 0.05
ASSIGN: assessing cardiovascular risk using SIGN guidelines; CHD: coronary heart disease; CVD: cardiovascular disease; HDL: high density lipoprotein; MWU: Mann Whitney U; SIGN: Scottish Intercollegiate Guidelines Network.


Gene_expression (disease) of high density lipoprotein in heart associated with coronary artery disease, cardiovascular disease and disorder of lipid metabolism
2) Confidence 0.57 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2876176 Disease Relevance 0.59 Pain Relevance 0
A substantial number of patients (10%) died from CVD events within 30 months, despite having LDL-C levels below 70 mg/dL (1.8 mmol/L).7 Similar were the findings in the Treating to New Targets (TNT) study, where the level of residual CVD risk remained high in patients treated with atorvastatin 10 mg/dL or 80 mg/dL.8,9 This residual CVD risk seems to depend at least partly on increased levels of triglycerides (TG) and decreased levels of high-density lipoprotein cholesterol (HDL-C).
Gene_expression (levels) of high-density lipoprotein cholesterol associated with cardiovascular disease and disorder of lipid metabolism
3) Confidence 0.24 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.35 Pain Relevance 0
Metabolic syndrome is characterized by a constellation of metabolic and anthropometric abnormalities, which include excess weight, hyperglycemia, hypertension, low concentration of high density lipoprotein (HDL) cholesterol and hypertriglyceridemia [1–3].
Gene_expression (concentration) of high density lipoprotein associated with hyperglycemia, congenital anomalies, hypertension, metabolic syndrome, hyperlipidemia and disorder of lipid metabolism
4) Confidence 0.16 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 1.01 Pain Relevance 0
Although our results overall suggest that there is no difference in the association between women and men the differences in HDLc levels and CHD risk between the sexes warranted specific examination of the association in women.
Gene_expression (levels) of HDLc associated with coronary artery disease
5) Confidence 0.07 Published 2004 Journal BMC Genet Section Body Doc Link PMC449704 Disease Relevance 0.56 Pain Relevance 0
Compared to the control group, SLE patients were younger, developed cardiovascular diseases (CAD, stenocardia, myocardial infarction, and cerebral stroke (p = 0.05) as well as arterial hypertension more often, had higher levels of hs-CRP and triglycerides, and lower levels of high density lipoprotein cholesterol (HDLC).
Gene_expression (levels) of HDLC associated with pressure and volume under development, angina, coronary artery disease, stroke, cardiovascular disease, systemic lupus erythematosus and myocardial infarction
6) Confidence 0.07 Published 2006 Journal Klin Med (Mosk) Section Abstract Doc Link 17201275 Disease Relevance 1.83 Pain Relevance 0.17
Compared to the control group, SLE patients were younger, developed cardiovascular diseases (CAD, stenocardia, myocardial infarction, and cerebral stroke (p = 0.05) as well as arterial hypertension more often, had higher levels of hs-CRP and triglycerides, and lower levels of high density lipoprotein cholesterol (HDLC).
Gene_expression (levels) of high density lipoprotein cholesterol associated with pressure and volume under development, angina, coronary artery disease, stroke, cardiovascular disease, systemic lupus erythematosus and myocardial infarction
7) Confidence 0.07 Published 2006 Journal Klin Med (Mosk) Section Abstract Doc Link 17201275 Disease Relevance 1.83 Pain Relevance 0.17
The high-density lipoprotein is made up of several particles with different composition and function [24,27,28].
Gene_expression (made) of high-density lipoprotein
8) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2940866 Disease Relevance 1.35 Pain Relevance 0.12
In general, a negative correlation between PAI and HDLC levels in the patients under study (r = -0.413; p = 0.02), it was higher in PA (r = -0.687; p = 0.02), but disappeared in CCHD (r = 0.027).
Gene_expression (levels) of HDLC associated with angina and coronary artery disease
9) Confidence 0.05 Published 1990 Journal Kardiologiia Section Abstract Doc Link 2395263 Disease Relevance 1.26 Pain Relevance 0.43
Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease

Background

Gene_expression (Levels) of high-density lipoprotein associated with sickle cell anemia and disorder of lipid metabolism
10) Confidence 0.05 Published 2010 Journal Lipids Health Dis Section Title Doc Link PMC2940866 Disease Relevance 0.91 Pain Relevance 0.08
A fasting blood sample of approximately 10 ml was taken to measure triglyceride, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), glucose and glycosylated haemoglobin (HbA1c) levels.
Gene_expression (levels) of high density lipoprotein in blood associated with disorder of lipid metabolism
11) Confidence 0.04 Published 2006 Journal Epidemiol Perspect Innov Section Body Doc Link PMC1462963 Disease Relevance 0.47 Pain Relevance 0
The levels of plasminogen activator inhibitor (PAI), protein C (pC), total cholesterol (TC), high and low density lipoprotein cholesterols (HDLC and LDLC), apolipoproteins A1 (apoA1) and B (apoB) were measured in 45 patients with coronary heart disease angiographically documented and 10 healthy subjects without coronary heart disease and coronary atherosclerosis as evidenced by coronary angiography and provocative tests.
Gene_expression (levels) of HDLC in heart associated with coronary artery disease and disorder of lipid metabolism
12) Confidence 0.03 Published 1990 Journal Kardiologiia Section Abstract Doc Link 2395263 Disease Relevance 0.79 Pain Relevance 0.20
Rats subjected to CMS exhibited a reduction in sucrose intake, 5-HT, 5-HIAA, IL-2, TC, HDLc and LDLc levels, as well as, diminished NK cell and LAK cell activities.
Gene_expression (levels) of HDLc in LAK cell associated with stress and disorder of lipid metabolism
13) Confidence 0.02 Published 2003 Journal Life Sci. Section Abstract Doc Link 14575813 Disease Relevance 0.90 Pain Relevance 0.18
Rats subjected to CMS exhibited a reduction in sucrose intake, 5-HT, 5-HIAA, IL-2, TC, HDLc and LDLc levels, as well as, diminished NK cell and LAK cell activities.
Gene_expression (levels) of HDLc in NK cell associated with stress and disorder of lipid metabolism
14) Confidence 0.01 Published 2003 Journal Life Sci. Section Abstract Doc Link 14575813 Disease Relevance 0.90 Pain Relevance 0.18

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