INT231950

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 3.70
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Myh1)
Anatomy Link Frequency
muscle 9
masseter 3
macrophages 1
T cells 1
Myh1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 85 99.70 Very High Very High Very High
Inflammation 75 99.50 Very High Very High Very High
addiction 5 86.16 High High
antagonist 11 60.44 Quite High
agonist 23 33.28 Quite Low
anesthesia 25 22.88 Low Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 90 99.50 Very High Very High Very High
Body Weight 126 95.04 Very High Very High Very High
Sprains And Strains 73 94.28 High High
Carcinoma 4 89.12 High High
Stress 2 87.28 High High
Cancer 65 86.08 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 141 83.96 Quite High
Foreign Bodies 9 78.96 Quite High
Frailty 24 74.72 Quite High
Rhabdomyosarcoma 1 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the gastrocnemius muscle, changes in the expression level of MyHC IIa were mostly consistent between the mi/mi and +/+.
Gene_expression (expression) of MyHC in muscle
1) Confidence 0.69 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0 Pain Relevance 0
No significant difference in the expression level of MyHC I mRNA was found between the mi/mi and +/+ mice at any time point.


Gene_expression (expression) of MyHC I mRNA
2) Confidence 0.69 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.06 Pain Relevance 0
In the gastrocnemius muscle of both the mi/mi and +/+, the expression level of MyHC I mRNA increased between 1 and 2 weeks of age, peaked between 2 and 4 weeks, and gradually decreased between 4 and 8 weeks.
Gene_expression (expression) of MyHC I mRNA in muscle
3) Confidence 0.69 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.12 Pain Relevance 0
At 8 weeks of age, the expression level of MyHC I mRNA in the masseter muscle of the mi/mi mice was 5.1-fold higher than that in the +/+ mice (p<0.01).
Gene_expression (expression) of MyHC I mRNA in muscle
4) Confidence 0.69 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.19 Pain Relevance 0
In the present study, there was no significant difference in the expression levels of MyHC IIa and IIb mRNAs between the mi/mi and +/+ mice.
Gene_expression (expression) of MyHC
5) Confidence 0.69 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0 Pain Relevance 0
In the masseter muscle of both the mi/mi and +/+, the expression level of MyHC I mRNA was high at 1 week of age and rapidly decreased between 1 and 2 weeks.
Gene_expression (expression) of MyHC I mRNA in masseter
6) Confidence 0.69 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.27 Pain Relevance 0
Together with the findings regarding MyHC I and IIx expression, the present findings suggests that proper chewing is essential for the normal growth of the masseter muscle, and that it is essential to provide a diet that induces proper occlusal activity for the normal growth of the mouse masseter muscle.
Gene_expression (expression) of IIx in muscle
7) Confidence 0.61 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.09 Pain Relevance 0
In the present study, we observed a marked difference in the expression of MyHC IIx at 3 and 4 weeks of age between the mi/mi and +/+ mice.
Gene_expression (expression) of IIx
8) Confidence 0.61 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.06 Pain Relevance 0
Together with the findings regarding MyHC I and IIx expression, the present findings suggests that proper chewing is essential for the normal growth of the masseter muscle, and that it is essential to provide a diet that induces proper occlusal activity for the normal growth of the mouse masseter muscle.
Gene_expression (expression) of MyHC I in muscle
9) Confidence 0.61 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.10 Pain Relevance 0
This seems to exclude the possibility that the mutation of mitf itself affects the expressions of MyHC isoform mRNAs.
Gene_expression (expressions) of MyHC
10) Confidence 0.60 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.05 Pain Relevance 0
No significant difference in the expression level of MyHC IIa mRNA was found between the mi/mi and +/+ mice at any time point.
Gene_expression (expression) of MyHC
11) Confidence 0.60 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0 Pain Relevance 0
The sequences of primers and the sizes of PCR products for MyHC I, IIa, IIx, and IIb were described previously [16] and are shown in Table 1.


Gene_expression (products) of MyHC I
12) Confidence 0.60 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.14 Pain Relevance 0
The expression level of MyHC IIa mRNA increased between 1 and 4 weeks of age, and then gradually decreased until 8 weeks of age.
Gene_expression (expression) of MyHC
13) Confidence 0.60 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0 Pain Relevance 0
No significant difference in the expression level of MyHC IIa mRNA was found between the mi/mi and +/+ mice at any time point.


Gene_expression (expression) of MyHC
14) Confidence 0.60 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0 Pain Relevance 0
In the present control conditions using the gastrocnemius muscles of mi/mi mice, there was no significant difference in the expression levels of MyHC isoform mRNAs between the mi/mi and +/+ mice.
Gene_expression (expression) of MyHC in muscles
15) Confidence 0.60 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.06 Pain Relevance 0
MyHC I is reported to disappear during the postnatal development of masseter muscle in the wild-type mouse and is not detectable in the adult masseter muscle [16,17].
Neg (not) Gene_expression (detectable) of MyHC I in masseter
16) Confidence 0.54 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.09 Pain Relevance 0
MyHC I is mainly expressed in slow-twitch myofibers, whereas MyHC IIa, IIx, and IIb are expressed in fast-twitch fibers.
Gene_expression (expressed) of MyHC
17) Confidence 0.54 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.06 Pain Relevance 0
MyHC I is mainly expressed in slow-twitch myofibers, whereas MyHC IIa, IIx, and IIb are expressed in fast-twitch fibers.
Gene_expression (expressed) of MyHC I
18) Confidence 0.54 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.05 Pain Relevance 0
Fig. (4) shows the changes in the expression of MyHC I mRNA in the masseter (A) and gastrocnemius (B) muscles between 1 and 8 weeks of age.
Gene_expression (expression) of MyHC I mRNA in muscles
19) Confidence 0.54 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.30 Pain Relevance 0
The expression levels of MyHC IIx mRNA in the mi/mi mice were 41% and 55% less than those in the +/+ mice at 3 weeks and 4 weeks of age, respectively (p<0.05).
Gene_expression (expression) of IIx
20) Confidence 0.52 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0 Pain Relevance 0

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