INT231961

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.01
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Hltf) nucleus (Hltf) helicase activity (Hltf)
DNA binding (Hltf) ligase activity (Hltf)
Anatomy Link Frequency
nerve 1
Hltf (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 13 100.00 Very High Very High Very High
adenocard 1 100.00 Very High Very High Very High
agonist 15 98.88 Very High Very High Very High
Inflammation 13 97.52 Very High Very High Very High
Neuropathic pain 10 94.76 High High
Pain 21 87.88 High High
spinal dorsal horn 1 82.64 Quite High
Dorsal horn neuron 1 79.12 Quite High
Central nervous system 10 66.24 Quite High
Peripheral nerve injury 3 63.92 Quite High
Disease Link Frequency Relevance Heat
Injury 7 98.28 Very High Very High Very High
INFLAMMATION 12 97.52 Very High Very High Very High
Nervous System Injury 22 96.96 Very High Very High Very High
Amputation 1 96.32 Very High Very High Very High
Neuropathic Pain 15 94.76 High High
Hyperlipidemia 2 92.16 High High
Pain 24 87.88 High High
Disorder Of Lipid Metabolism 288 86.88 High High
Atherosclerosis 49 84.40 Quite High
Targeted Disruption 12 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with neuronal changes, activation or increased expression of immediate early genes in the ACC neurons, such as c-fos, Egr1 and 3',5'-cyclic adenosine-monophosphate response element-binding protein (CREB) have been reported after different injury conditions (inflammation, nerve injury or amputation) [10,12,14].
Gene_expression (expression) of adenosine-monophosphate response element-binding protein in nerve associated with adenocard, nervous system injury, inflammation, injury, amputation and anterior cingulate cortex
1) Confidence 0.28 Published 2008 Journal Mol Pain Section Body Doc Link PMC2374773 Disease Relevance 1.19 Pain Relevance 0.82
Since LXR agonists induce genes that stimulate lipogenesis, including the sterol response element binding protein (SREBP1-c) and fatty acid synthetase (FAS).
Gene_expression (acid synthetase) of sterol response element binding protein associated with agonist
2) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.82 Pain Relevance 0.28

General Comments

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