INT23198

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Context Info
Confidence 0.41
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.75
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (LDLR) small molecule metabolic process (LDLR) plasma membrane (LDLR)
lipid metabolic process (LDLR) lysosome (LDLR)
Anatomy Mention Frequency
liver 1
fibroblast 1
LDLR (Homo sapiens)
Pain Term Frequency Confidence Heat
Inflammation 24 73.76 Quite High
Angina 5 58.88 Quite High
Inflammatory marker 1 24.28 Low Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Atherosclerosis 23 99.72 Very High Very High Very High
Cardiovascular Disease 95 99.40 Very High Very High Very High
Coronary Artery Disease 80 98.56 Very High Very High Very High
Hyperlipidemia 18 98.14 Very High Very High Very High
Disorder Of Lipid Metabolism 142 94.80 High High
Pathologic Constriction 3 88.60 High High
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26 86.24 High High
Appetite Loss 6 85.84 High High
Chronic Renal Failure 19 83.76 Quite High
Acute Coronary Syndrome 38 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical diagnosis, homozygous familial hypercholesterolaemia, was confirmed by: (1) investigation of the family revealing hypercholesterolaemia in both her parents and siblings; (2) fibroblast association studies, in which the specific association of low density lipoprotein (LDL) was 35% of normal; and (3) LDL turnover study, in which the fractional catabolic rate of LDL was decreased to 0.213 pools/day.
LDL Binding (association) of low density lipoprotein in fibroblast associated with hyperlipidemia
1) Confidence 0.41 Published 1990 Journal Neth J Med Section Abstract Doc Link 2395495 Disease Relevance 0.64 Pain Relevance 0.06
This phenotype is considered to be of particular importance in the pathogenesis of atherosclerosis, since these LDL bind less avidly to the LDL receptor which mediates its endocytosis in the liver or peripheral tissues (Liu and Rosner, 2006).
LDL Binding (bind) of LDL receptor in liver associated with atherosclerosis
2) Confidence 0.34 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.02 Pain Relevance 0.10
EGTA is a known blocker of the interaction of LDL with LDLR [21].
LDL Binding (interaction) of LDLR
3) Confidence 0.27 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.08 Pain Relevance 0
ApoB is also essential for the binding of LDL particles to the LDL receptor for cellular uptake and degradation of LDL particles (Simon et al. 2005).
LDL Binding (binding) of LDL receptor
4) Confidence 0.25 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.81 Pain Relevance 0
Treatment with fenofibrate shifts the ratio of LDL-C particle subspecies from small, dense, atherogenic LDL particles (LDL 4 and LDL 5) to large, buoyant ones (LDL 3).54 These larger, less dense LDL particles show higher affinity for the LDL receptor, while an association between small dense LDL and increased CVD risk has long been established.
LDL Binding (association) of LDL 4 associated with cardiovascular disease
5) Confidence 0.21 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 1.53 Pain Relevance 0
LDL heterogeneity, along with dietary and genetic influences, is now well recognized as an indicator of differences in lipoprotein composition, size, and metabolism.1-3 For these reasons, small, dense low-density lipoprotein (sd-LDL) is viewed as an important CAD risk factor.1,4,5
LDL Binding (recognized) of low-density lipoprotein associated with coronary artery disease
6) Confidence 0.02 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2688162 Disease Relevance 0.53 Pain Relevance 0

General Comments

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