INT231982

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 7.76
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cells 2
ECM 2
lumen 1
platelet 1
lung 1
Tsp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 11 99.68 Very High Very High Very High
cytokine 42 99.16 Very High Very High Very High
tolerance 21 98.20 Very High Very High Very High
Inflammation 381 97.96 Very High Very High Very High
agonist 8 60.20 Quite High
addiction 3 50.00 Quite Low
chemokine 22 48.24 Quite Low
cINOD 7 28.68 Quite Low
imagery 20 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 440 98.82 Very High Very High Very High
Toxicity 6 98.72 Very High Very High Very High
INFLAMMATION 378 97.96 Very High Very High Very High
Colitis 35 96.64 Very High Very High Very High
Apoptosis 82 96.60 Very High Very High Very High
Bladder Cancer 182 96.08 Very High Very High Very High
Targeted Disruption 50 92.20 High High
Hemorrhage 14 92.00 High High
Inflammatory Bowel Disease 140 91.08 High High
Adenoma 49 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An important mechanism could be the TSP1/NO interaction.
TSP1 Neg (NO) Binding (interaction) of
1) Confidence 0.46 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.97 Pain Relevance 0.08
The thrombospondins (TSP) include five calcium-binding extracellular glycoproteins.(13,14) TSP1 was the first to be identified and was detected in the ?
TSP1 Binding (binding) of
2) Confidence 0.36 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.73 Pain Relevance 0.23
In that study, the anti-tumor activity of this molecule is specifically mediated in its TSP1 binding site.(72,73)
TSP1 Binding (binding) of associated with cancer
3) Confidence 0.36 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.29 Pain Relevance 0.06
TSR of TSP1 block vascular endothelial growth factor (VEGF)-induced migration of human umbilical vein endothelial cells (HUVEC) which lack CD36 and this inhibition is mediated by beta1 integrins.(35) TSP1 also interacts with other receptors involved in angiogenesis and inflammation such as integrin ?
TSP1 Binding (interacts) of in endothelial cells associated with inflammation
4) Confidence 0.34 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.42 Pain Relevance 0.14
Upon binding with CD47, TSP1 promotes the activation of thymus-derived CD4+ CD25+ T regulatory cells (Tregs).
TSP1 Binding (binding) of in thymus
5) Confidence 0.34 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.50 Pain Relevance 0.23
By interacting with CD47, TSP1 might contribute to the quiescence state and self-tolerance in tissues such as intestine and lung.
TSP1 Binding (interacting) of in lung associated with tolerance
6) Confidence 0.34 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.46 Pain Relevance 0.22
Originally, TSP1 was identified as a component of platelet ?
TSP1 Binding (component) of in platelet
7) Confidence 0.32 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.71 Pain Relevance 0.03
These same TSP1 active peptides have been shown to bind to CD36, and neutralizing antibodies to CD36 were able to block native TSP1 and active peptide fragments from inhibition of endothelial cell migration [27].
TSP1 Binding (bind) of in endothelial cell
8) Confidence 0.31 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.36 Pain Relevance 0
The staining of the TSP-1 and Tn-C associate with many of the neovascular and microvascular lumen within the tumor, a phenomenon consistent with one of the TAF cell phenotypes, the pericyte.
TSP-1 Binding (associate) of in lumen associated with cancer
9) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2661372 Disease Relevance 0.97 Pain Relevance 0
TSP-1 and TSP-2 bind matrix metalloproteinase-2, and thereby act to clear this matrix metalloproteinase from the pericellular ECM [5].
TSP-1 Binding (bind) of in ECM associated with metalloproteinase
10) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.09 Pain Relevance 0.15
The thrombospondins (TSPs) are multifunctional matricellular proteins; TSP-1 and TSP-2 have strong anti-angiogenic properties, are present in a number of tissues where they bind to the extracellular matrix (ECM) and, in turn, are themselves able to bind receptors, enzymes, cytokines, proteases, and other ECM proteins [1-6].
TSP-1 Binding (bind) of in extracellular matrix associated with cytokine
11) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.08 Pain Relevance 0.14
Because of their thiol rich content, MTs can bind to a number of trace
MTs Binding (bind) of
12) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.23 Pain Relevance 0
By interacting with CD47, TSP1 might contribute to the quiescence state and self-tolerance in tissues such as intestine and lung.
TSP1 Binding (interacting) of in intestine associated with tolerance
13) Confidence 0.12 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.46 Pain Relevance 0.22
Because of their thiol rich content, MTs can bind to a number of trace
MTs Binding (bind) of
14) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.23 Pain Relevance 0
Furthermore, MTs are among the most abundant components interacting with
MTs Binding (interacting) of
15) Confidence 0.11 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.25 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox