INT231984

Context Info Confidence 0.51 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 7 Disease Relevance 6.01 Pain Relevance 0.28

Anatomy Link Frequency endothelial cell 1 vessels 1 bladder 1 Tsp1 (Mus musculus)

Pain Link Frequency Relevance Heat inflammatory response 1 99.00 inflammatory 42 92.96 metalloproteinase 9 92.60 addiction 3 50.00 cytokine 4 27.32 agonist 12 10.88 Imagery 15 5.00 isoflurane 6 5.00 anesthesia 3 5.00 paracetamol 3 5.00

Disease Link Frequency Relevance Heat Corneal Neovascularization 6 99.84 Cancer 499 99.16 INFLAMMATION 42 98.82 Bladder Cancer 273 98.28 Prostate Cancer 75 98.00 Hemorrhage 2 97.60 Diarrhoea 1 96.80 Weight Loss 1 95.76 Benign Prostatic Hypertrophy 3 94.12 Colitis 5 91.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We examined the protein expression of TSP1 in human BC paired with normal bladder tissue from the same patients and found that the ~ 50 kDa TSP1 anti-angiogenic fragment is decreased in human urothelial cancer tissue.

Negative_regulation (decreased) of TSP1 in bladder associated with cancer and bladder cancer

1) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.25 Pain Relevance 0

Furthermore, TSP1 inhibition of corneal neovascularization was impaired in CD36 null animals [28].

Negative_regulation (inhibition) of TSP1 associated with corneal neovascularization

2) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.57 Pain Relevance 0

TSP1 is one of the most studied endogenous inhibitor of angiogenesis, and downregulation of TSP1 is common in a variety of tumor types, including prostate cancer [10].

Negative_regulation (downregulation) of TSP1 associated with cancer and prostate cancer

3) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.85 Pain Relevance 0.12

This is in accordance with our study, where decreased expression of ADAMTS1 was associated with increased TSP1 and a switch from large vessels into small vessels, while overexpression of ADAMTS1 resulted in loss of TSP1 and a switch back to larger vessels.

Negative_regulation (loss) of TSP1 in vessels

4) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.74 Pain Relevance 0

This finding indicates that DSS induces an inflammatory response as an early effect, which was intensified by the deficiency of TSP1.

Negative_regulation (deficiency) of TSP1 associated with inflammatory response

5) Confidence 0.41 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.24 Pain Relevance 0.16

These same TSP1 active peptides have been shown to bind to CD36, and neutralizing antibodies to CD36 were able to block native TSP1 and active peptide fragments from inhibition of endothelial cell migration [27].

Negative_regulation (block) of TSP1 in endothelial cell

6) Confidence 0.37 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.48 Pain Relevance 0

Downregulation of ADAMTS1 in LNCaP resulted in increased levels of TSP1 (Figure 6A, B), and upregulation of ADAMTS1 in LNCaP-19 was associated with decreased levels of TSP1 (Figure 6C, D).

Negative_regulation (decreased) of TSP1

7) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.88 Pain Relevance 0

General Comments

This test has worked.