INT231987
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1. | |||||||||||||||
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Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1. | |||||||||||||||
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Eight of the ten paired samples had greater TSP1 protein expression in the normal tissue compared to the BC. | |||||||||||||||
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Paired normal and BC frozen biopsies from ten male patients were also examined for expression of TSP1 protein by western blot analysis. | |||||||||||||||
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One paired sample did not express TSP1 in either the normal or tumor tissue, and one paired sample showed higher TSP1 expression in the BC rather than the normal tissue. | |||||||||||||||
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We examined TSP1 expression in high grade and high stage human BC. | |||||||||||||||
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In addition, the same study also found that castration of rats increases TSP1 expression and decreases microvessel density counts in the prostate [32]. | |||||||||||||||
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Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration. | |||||||||||||||
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One paired sample did not express TSP1 in either the normal or tumor tissue, and one paired sample showed higher TSP1 expression in the BC rather than the normal tissue. | |||||||||||||||
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Metastatic prostate cancer patients treated with androgen deprivation therapy expressed a significantly higher TSP1 immunoreactivity in prostatic adenocarcinoma when compared to other metastatic prostate cancer patients who did not receive hormonal therapy [48]. | |||||||||||||||
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Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1. | |||||||||||||||
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The molecular weight of TSP1 expressed in mouse and human bladders was slightly less than 50 kDa. | |||||||||||||||
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In addition, prostate biopsies indicated that patients with metastatic prostate cancer had significantly less TSP1 expression than patients with localized prostate cancer, who also had significantly lower TSP1 expression than patients with benign prostatic hyperplasia [48]. | |||||||||||||||
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Others have reported changes in TSP1 expression in response to androgens in prostate and breast cancer. | |||||||||||||||
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Wild-type mouse expressed significantly more TSP1 than transgenic UPII-SV40T in the bladder (p = 0.0326, Fig. 7A; paired, two-tailed, student's t-test). | |||||||||||||||
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Others have reported changes in TSP1 expression in response to androgens in prostate and breast cancer. | |||||||||||||||
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Secreted TSP1 was found to be expressed in the bladder stroma of all animals, but TSP1 expression in the urothelium was greater in castrated animals when compared to intact animals (Figure 6). | |||||||||||||||
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TSP1 expression was greater in 8 (specimens 2, 3, 4, 5, 6, 7, 9, 10; Fig. 8A) of the normal bladder specimens compared to the paired BC specimen. | |||||||||||||||
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Castration of UPII-SV40T male animals resulted in a modest (but not statistically significant) increase in TSP1 expression in bladder protein at days 27 post-castration compared to their intact counterparts (Fig. 7B). | |||||||||||||||
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We examined the protein expression of TSP1 in human BC paired with normal bladder tissue from the same patients and found that the ~ 50 kDa TSP1 anti-angiogenic fragment is decreased in human urothelial cancer tissue. | |||||||||||||||
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