INT231987

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 3
Speculated 6
Reported most in Body
Documents 66
Total Number 75
Disease Relevance 62.58
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
bladder 14
lymph node 2
uterus 2
Brain 1
annulus 1
Tsp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 465 98.88 Very High Very High Very High
agonist 220 97.16 Very High Very High Very High
cytokine 53 94.56 High High
metalloproteinase 26 82.72 Quite High
tolerance 27 81.48 Quite High
imagery 295 81.12 Quite High
addiction 57 75.00 Quite High
Inflammatory response 12 57.28 Quite High
isoflurane 114 36.12 Quite Low
chemokine 27 6.28 Low Low
Disease Link Frequency Relevance Heat
Cancer 3767 100.00 Very High Very High Very High
Targeted Disruption 845 100.00 Very High Very High Very High
Apoptosis 261 100.00 Very High Very High Very High
Colon Cancer 90 100.00 Very High Very High Very High
Malignant Neoplastic Disease 140 99.92 Very High Very High Very High
Bladder Cancer 5005 99.84 Very High Very High Very High
Reprotox - General 1 440 99.52 Very High Very High Very High
Metastasis 117 99.36 Very High Very High Very High
Breast Cancer 234 99.32 Very High Very High Very High
Recurrence 110 99.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1.
Gene_expression (expression) of TSP1 associated with cancer, bladder cancer and recurrence
1) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.36 Pain Relevance 0
Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1.
Gene_expression (expression) of TSP1 associated with cancer, bladder cancer and recurrence
2) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.43 Pain Relevance 0
Eight of the ten paired samples had greater TSP1 protein expression in the normal tissue compared to the BC.
Gene_expression (expression) of TSP1 associated with bladder cancer
3) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.32 Pain Relevance 0
Paired normal and BC frozen biopsies from ten male patients were also examined for expression of TSP1 protein by western blot analysis.
Spec (examined) Gene_expression (expression) of TSP1 associated with bladder cancer
4) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.56 Pain Relevance 0
One paired sample did not express TSP1 in either the normal or tumor tissue, and one paired sample showed higher TSP1 expression in the BC rather than the normal tissue.
Gene_expression (expression) of TSP1 associated with cancer and bladder cancer
5) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.42 Pain Relevance 0
We examined TSP1 expression in high grade and high stage human BC.
Spec (examined) Gene_expression (expression) of TSP1 associated with bladder cancer
6) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.95 Pain Relevance 0
In addition, the same study also found that castration of rats increases TSP1 expression and decreases microvessel density counts in the prostate [32].
Gene_expression (expression) of TSP1
7) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.66 Pain Relevance 0.05
Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration.
Gene_expression (expression) of TSP1 associated with cancer
8) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.72 Pain Relevance 0.03
One paired sample did not express TSP1 in either the normal or tumor tissue, and one paired sample showed higher TSP1 expression in the BC rather than the normal tissue.
Neg (not) Gene_expression (express) of TSP1 associated with cancer and bladder cancer
9) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.35 Pain Relevance 0
Metastatic prostate cancer patients treated with androgen deprivation therapy expressed a significantly higher TSP1 immunoreactivity in prostatic adenocarcinoma when compared to other metastatic prostate cancer patients who did not receive hormonal therapy [48].
Gene_expression (expressed) of TSP1 associated with adenocarcinoma and reprotox - general 1
10) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.74 Pain Relevance 0.04
Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1.
Gene_expression (overexpressed) of TSP1 associated with cancer, bladder cancer and recurrence
11) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.25 Pain Relevance 0
The molecular weight of TSP1 expressed in mouse and human bladders was slightly less than 50 kDa.
Gene_expression (expressed) of TSP1 in bladders
12) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.31 Pain Relevance 0
In addition, prostate biopsies indicated that patients with metastatic prostate cancer had significantly less TSP1 expression than patients with localized prostate cancer, who also had significantly lower TSP1 expression than patients with benign prostatic hyperplasia [48].
Gene_expression (expression) of TSP1 associated with benign prostatic hypertrophy and reprotox - general 1
13) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.20 Pain Relevance 0
Others have reported changes in TSP1 expression in response to androgens in prostate and breast cancer.
Gene_expression (expression) of TSP1 associated with breast cancer
14) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.76 Pain Relevance 0.08
Wild-type mouse expressed significantly more TSP1 than transgenic UPII-SV40T in the bladder (p = 0.0326, Fig. 7A; paired, two-tailed, student's t-test).
Gene_expression (expressed) of TSP1 in bladder associated with targeted disruption
15) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.36 Pain Relevance 0
Others have reported changes in TSP1 expression in response to androgens in prostate and breast cancer.
Gene_expression (expression) of TSP1 associated with breast cancer
16) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.73 Pain Relevance 0.05
Secreted TSP1 was found to be expressed in the bladder stroma of all animals, but TSP1 expression in the urothelium was greater in castrated animals when compared to intact animals (Figure 6).
Gene_expression (expressed) of TSP1 in bladder
17) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.54 Pain Relevance 0
TSP1 expression was greater in 8 (specimens 2, 3, 4, 5, 6, 7, 9, 10; Fig. 8A) of the normal bladder specimens compared to the paired BC specimen.
Gene_expression (expression) of TSP1 in bladder associated with bladder cancer
18) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.57 Pain Relevance 0
Castration of UPII-SV40T male animals resulted in a modest (but not statistically significant) increase in TSP1 expression in bladder protein at days 2–7 post-castration compared to their intact counterparts (Fig. 7B).
Gene_expression (expression) of TSP1 in bladder
19) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.40 Pain Relevance 0
We examined the protein expression of TSP1 in human BC paired with normal bladder tissue from the same patients and found that the ~ 50 kDa TSP1 anti-angiogenic fragment is decreased in human urothelial cancer tissue.
Spec (examined) Gene_expression (expression) of TSP1 in bladder associated with cancer and bladder cancer
20) Confidence 0.67 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.32 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox