INT231989

Context Info Confidence 0.53 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 9 Disease Relevance 8.27 Pain Relevance 0.59

Anatomy Link Frequency vessels 1 bladder 1 annulus 1 Tsp1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 126 97.40 tolerance 9 85.12 Inflammatory response 3 76.32 addiction 3 75.00 chemokine 3 58.96 cINOD 3 39.40 metalloproteinase 10 9.76 cytokine 13 5.64 imagery 15 5.00 agonist 12 5.00

Disease Link Frequency Relevance Heat Thrombosis 3 99.78 Cancer 428 99.08 Inflammatory Bowel Disease 60 98.80 INFLAMMATION 126 97.40 Prostate Cancer 50 97.32 Recurrence 6 97.04 Bladder Cancer 273 96.32 Malignant Neoplastic Disease 18 88.96 Colitis 15 86.80 Necrosis 3 86.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This is in accordance with our study, where decreased expression of ADAMTS1 was associated with increased TSP1 and a switch from large vessels into small vessels, while overexpression of ADAMTS1 resulted in loss of TSP1 and a switch back to larger vessels.

Positive_regulation (increased) of TSP1 in vessels

1) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.80 Pain Relevance 0

These studies strongly suggest an important role of TSP1 in the mechanisms developing IBD and cancer.

Positive_regulation (role) of TSP1 associated with inflammatory bowel disease and cancer

2) Confidence 0.48 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.85 Pain Relevance 0.31

Fibrin deposits and thrombus were also positive for TSP1(48).

Positive_regulation (positive) of TSP1 associated with thrombosis

3) Confidence 0.45 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.25 Pain Relevance 0.12

Upregulation of TSP1 has been detected in DSS induced-lesions using gene microarray technology(49).

Positive_regulation (Upregulation) of TSP1

4) Confidence 0.45 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.25 Pain Relevance 0.12

Although we have not tested whether upregulation of TSP1 might contribute to the lack of vascularization of the annulus in TSP-2-null mice, the evidence in the literature suggests that compensation by either of the two TSPs does not occur [32].

Positive_regulation (upregulation) of TSP1 in annulus

5) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575610 Disease Relevance 0.14 Pain Relevance 0

Castration increased TSP1 levels in UPII-SV40T mice compared to intact mice.

Positive_regulation (increased) of TSP1

6) Confidence 0.40 Published 2008 Journal BMC Urol Section Abstract Doc Link PMC2374790 Disease Relevance 1.19 Pain Relevance 0.04

Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1.

Positive_regulation (levels) of TSP1 associated with cancer, bladder cancer and recurrence

7) Confidence 0.40 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.33 Pain Relevance 0

ADAMTS1 has previously been reported to regulate angiogenesis by cleaving TSP1, which results in the release of TSP1 from ECM and thereby to decreased angiogenesis [9].

Positive_regulation (cleaving) of TSP1

8) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.96 Pain Relevance 0

Seventeen days after castration in UPII-SV40T, TSP1 bladder protein expression was increased 3.8-fold (p = 0.0154) compared to intact animals (Fig. 7B, C).

Positive_regulation (increased) of TSP1 in bladder

9) Confidence 0.19 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.50 Pain Relevance 0

General Comments

This test has worked.