INT231991

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2009
Negated 0
Speculated 3
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 7.30
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Tsp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 28 79.56 Quite High
addiction 7 75.00 Quite High
Inflammation 71 50.00 Quite Low
imagery 35 5.00 Very Low Very Low Very Low
isoflurane 14 5.00 Very Low Very Low Very Low
Paracetamol 8 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 10 100.00 Very High Very High Very High
Breast Cancer 28 99.50 Very High Very High Very High
Cancer 371 99.24 Very High Very High Very High
Bladder Cancer 637 98.88 Very High Very High Very High
Adenoma 7 95.44 Very High Very High Very High
Reprotox - General 1 56 94.84 High High
Carcinoma 12 94.40 High High
Adenocarcinoma 9 92.84 High High
Toxicity 2 89.64 High High
Malignant Neoplastic Disease 16 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration.
Spec (possibly) Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with cancer
1) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.83 Pain Relevance 0.07
Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration.
Spec (possibly) Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with cancer
2) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.72 Pain Relevance 0.03
Testosterone administered in vitro to breast cancer cells has been shown to decrease TSP1 expression at the mRNA and protein levels, and this effect can be inhibited by pre-incubation with the anti-androgen flutamide [33].
Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with breast cancer
3) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.80 Pain Relevance 0.04
Campbell et al. [31] showed reduced TSP1 expression in both high and low grade BC and suggested that the switch from an anti-angiogenic to angiogenic phenotype occurs early in BC development.
Negative_regulation (reduced) of Gene_expression (expression) of TSP1 associated with bladder cancer
4) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.02 Pain Relevance 0
Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration.
Spec (possibly) Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with cancer
5) Confidence 0.37 Published 2008 Journal BMC Urol Section Abstract Doc Link PMC2374790 Disease Relevance 0.84 Pain Relevance 0.04
Additionally, androgens inhibit TSP1 expression in androgen-responsive tissues in rodents.
Negative_regulation (inhibit) of Gene_expression (expression) of TSP1
6) Confidence 0.37 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.74 Pain Relevance 0
Treating mouse breast cancer cells with testosterone decreased de novo TSP1 synthesis (thus decreasing TSP1 expression at the mRNA and protein levels), and this effect was abrogated by administration of the anti-androgen flutamide [33], suggesting androgen-regulated angiogenesis.
Negative_regulation (decreasing) of Gene_expression (expression) of TSP1 associated with breast cancer
7) Confidence 0.37 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.81 Pain Relevance 0
Clinical studies have reported a decrease in TSP1 protein expression in human colorectal carcinomas.(60,61) When TSP1?
Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with colon cancer
8) Confidence 0.36 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.27 Pain Relevance 0
MTs are present in a great
Negative_regulation (great) of Gene_expression (present) of MTs
9) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.25 Pain Relevance 0

General Comments

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