INT231991

Context Info Confidence 0.51 First Reported 2008 Last Reported 2009 Negated 0 Speculated 3 Reported most in Body Documents 6 Total Number 9 Disease Relevance 7.30 Pain Relevance 0.18

Tsp1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 28 79.56 addiction 7 75.00 Inflammation 71 50.00 imagery 35 5.00 isoflurane 14 5.00 Paracetamol 8 5.00 cytokine 7 5.00 chemokine 5 5.00 tolerance 3 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Colon Cancer 10 100.00 Breast Cancer 28 99.50 Cancer 371 99.24 Bladder Cancer 637 98.88 Adenoma 7 95.44 Reprotox - General 1 56 94.84 Carcinoma 12 94.40 Adenocarcinoma 9 92.84 Toxicity 2 89.64 Malignant Neoplastic Disease 16 88.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration.

Spec (possibly) Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with cancer

1) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.83 Pain Relevance 0.07

Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration.

Spec (possibly) Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with cancer

2) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.72 Pain Relevance 0.03

Testosterone administered in vitro to breast cancer cells has been shown to decrease TSP1 expression at the mRNA and protein levels, and this effect can be inhibited by pre-incubation with the anti-androgen flutamide [33].

Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with breast cancer

3) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.80 Pain Relevance 0.04

Campbell et al. [31] showed reduced TSP1 expression in both high and low grade BC and suggested that the switch from an anti-angiogenic to angiogenic phenotype occurs early in BC development.

Negative_regulation (reduced) of Gene_expression (expression) of TSP1 associated with bladder cancer

4) Confidence 0.51 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.02 Pain Relevance 0

Androgens increase tumor cell growth in vitro and in vivo and decrease TSP1 expression, possibly explaining the therapeutic effect of castration.

Spec (possibly) Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with cancer

5) Confidence 0.37 Published 2008 Journal BMC Urol Section Abstract Doc Link PMC2374790 Disease Relevance 0.84 Pain Relevance 0.04

Additionally, androgens inhibit TSP1 expression in androgen-responsive tissues in rodents.

Negative_regulation (inhibit) of Gene_expression (expression) of TSP1

6) Confidence 0.37 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.74 Pain Relevance 0

Treating mouse breast cancer cells with testosterone decreased de novo TSP1 synthesis (thus decreasing TSP1 expression at the mRNA and protein levels), and this effect was abrogated by administration of the anti-androgen flutamide [33], suggesting androgen-regulated angiogenesis.

Negative_regulation (decreasing) of Gene_expression (expression) of TSP1 associated with breast cancer

7) Confidence 0.37 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.81 Pain Relevance 0

Clinical studies have reported a decrease in TSP1 protein expression in human colorectal carcinomas.(60,61) When TSP1?

Negative_regulation (decrease) of Gene_expression (expression) of TSP1 associated with colon cancer

8) Confidence 0.36 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.27 Pain Relevance 0

MTs are present in a great

Negative_regulation (great) of Gene_expression (present) of MTs

9) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2679981 Disease Relevance 0.25 Pain Relevance 0

General Comments

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