INT231995

Context Info Confidence 0.60 First Reported 2008 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 15 Total Number 15 Disease Relevance 15.21 Pain Relevance 0.18

Anatomy Link Frequency bladder 8 Tsp1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 56 96.60 addiction 14 75.00 Inflammation 42 51.00 imagery 70 5.00 isoflurane 28 5.00 Paracetamol 14 5.00 cytokine 4 5.00 tolerance 3 5.00 cINOD 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Bladder Cancer 1274 99.84 Cancer 719 99.68 Reprotox - General 1 112 99.62 Recurrence 28 99.26 Benign Prostatic Hypertrophy 14 99.20 Targeted Disruption 210 99.08 Malignant Neoplastic Disease 30 97.92 Colon Cancer 10 90.08 Breast Cancer 56 89.52 Adenocarcinoma 16 83.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, the same study also found that castration of rats increases TSP1 expression and decreases microvessel density counts in the prostate [32].

Positive_regulation (increases) of Gene_expression (expression) of TSP1

1) Confidence 0.60 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.67 Pain Relevance 0.05

One paired sample did not express TSP1 in either the normal or tumor tissue, and one paired sample showed higher TSP1 expression in the BC rather than the normal tissue.

Positive_regulation (higher) of Gene_expression (expression) of TSP1 associated with cancer and bladder cancer

2) Confidence 0.60 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.42 Pain Relevance 0

Castration of UPII-SV40T male animals resulted in a modest (but not statistically significant) increase in TSP1 expression in bladder protein at days 2–7 post-castration compared to their intact counterparts (Fig. 7B).

Neg (not) Positive_regulation (increase) of Gene_expression (expression) of TSP1 in bladder

3) Confidence 0.60 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.41 Pain Relevance 0

Seventeen days after castration in UPII-SV40T, TSP1 bladder protein expression was increased 3.8-fold (p = 0.0154) compared to intact animals (Fig. 7B, C).

Positive_regulation (increased) of Gene_expression (expression) of TSP1 in bladder

4) Confidence 0.60 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.50 Pain Relevance 0

Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1.

Positive_regulation (dependent) of Gene_expression (expression) of TSP1 associated with cancer, bladder cancer and recurrence

5) Confidence 0.60 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.36 Pain Relevance 0

Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TSP1 associated with cancer, bladder cancer and recurrence

6) Confidence 0.60 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.25 Pain Relevance 0

Furthermore, castration increased the TSP1 protein expression in both wild-type and transgenic animal bladders.

Positive_regulation (increased) of Gene_expression (expression) of TSP1 in bladders associated with targeted disruption

7) Confidence 0.60 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.85 Pain Relevance 0.03

Interestingly, mice overexpressing TSP1 showed tumor growth delay or inhibition.(59)

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of TSP1 associated with cancer

8) Confidence 0.48 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.17 Pain Relevance 0.03

Grossfeld et al. [29] found that patients with low TSP1 expression in BC had an increased risk of recurrence and decreased survival and that the expression of TSP1 was dependent on p53 expression: 96% of tumors with wildtype p53 expressed moderate to high levels of TSP1 protein, and only 58% of tumors with altered p53 protein overexpressed TSP1.

Positive_regulation (low) of Gene_expression (expression) of TSP1 associated with cancer, bladder cancer and recurrence

9) Confidence 0.43 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.43 Pain Relevance 0

In addition, prostate biopsies indicated that patients with metastatic prostate cancer had significantly less TSP1 expression than patients with localized prostate cancer, who also had significantly lower TSP1 expression than patients with benign prostatic hyperplasia [48].

Positive_regulation (less) of Gene_expression (expression) of TSP1 associated with benign prostatic hypertrophy and reprotox - general 1

10) Confidence 0.43 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.13 Pain Relevance 0

In addition, prostate biopsies indicated that patients with metastatic prostate cancer had significantly less TSP1 expression than patients with localized prostate cancer, who also had significantly lower TSP1 expression than patients with benign prostatic hyperplasia [48].

Positive_regulation (lower) of Gene_expression (expression) of TSP1 associated with benign prostatic hypertrophy and reprotox - general 1

11) Confidence 0.43 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.20 Pain Relevance 0

AR expression was higher in patient samples in which TSP1 expression was higher, except in specimen 1 where AR expression was actually higher in the tumor sample and TSP1 was not detected in either the normal or BC sample (data not shown).

Positive_regulation (higher) of Gene_expression (expression) of TSP1 associated with cancer and bladder cancer

12) Confidence 0.40 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.74 Pain Relevance 0

TSP1 protein expression was higher in 8 of 10 human bladder biopsies of normal versus malignant tissue from the same patients.

Positive_regulation (higher) of Gene_expression (expression) of TSP1 in bladder associated with malignant neoplastic disease

13) Confidence 0.40 Published 2008 Journal BMC Urol Section Abstract Doc Link PMC2374790 Disease Relevance 1.15 Pain Relevance 0.04

Castrated male rats had increased expression of TSP1 and decreased microvessel density in the prostate, which could be reversed by administration of testosterone [32].

Positive_regulation (increased) of Gene_expression (expression) of TSP1

14) Confidence 0.40 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.75 Pain Relevance 0

Castration increased TSP1 levels in UPII-SV40T mice compared to intact mice.

Positive_regulation (increased) of Gene_expression (levels) of TSP1

15) Confidence 0.40 Published 2008 Journal BMC Urol Section Abstract Doc Link PMC2374790 Disease Relevance 1.19 Pain Relevance 0.04

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