INT232005

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Cd36) transport (Cd36) mitochondrion (Cd36)
cell adhesion (Cd36) Golgi apparatus (Cd36) plasma membrane (Cd36)
Anatomy Link Frequency
endothelial cell 1
Cd36 (Mus musculus)
Tsp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 96.80 Very High Very High Very High
Inflammation 84 87.76 High High
addiction 1 50.00 Quite Low
tolerance 6 9.96 Low Low
imagery 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 23 98.68 Very High Very High Very High
Hemorrhage 4 98.54 Very High Very High Very High
Colitis 10 97.36 Very High Very High Very High
Corneal Neovascularization 2 90.56 High High
Cancer 88 89.92 High High
INFLAMMATION 84 87.76 High High
Adenoma 14 83.16 Quite High
Brain Tumor 2 74.00 Quite High
Osteogenic Sarcomas 2 64.12 Quite High
Lymphatic System Cancer 2 63.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the DSS model of induced colitis, ABT-510 consistently diminished angiogenesis and bleeding in treated mice.(48) This peptide is an analogue of the heptapeptide of TSP1 that interacts with CD36; thus, induction of endothelial apoptosis and decreased angiogenesis were expected.
CD36 Binding (interacts) of TSP1 associated with colitis, hemorrhage and apoptosis
1) Confidence 0.25 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 1.28 Pain Relevance 0.07
Of great importance is the interaction of TSP1 with the scavenger receptor CD36.
CD36 Binding (interaction) of TSP1
2) Confidence 0.20 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2600574 Disease Relevance 0.16 Pain Relevance 0.09
These same TSP1 active peptides have been shown to bind to CD36, and neutralizing antibodies to CD36 were able to block native TSP1 and active peptide fragments from inhibition of endothelial cell migration [27].
CD36 Binding (bind) of TSP1 in endothelial cell
3) Confidence 0.19 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.36 Pain Relevance 0

General Comments

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