INT232015

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPING1, F12) extracellular region (SERPING1, F12) peptidase activity (F12)
plasma membrane (F12)
SERPING1 (Homo sapiens)
F12 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 25 95.32 Very High Very High Very High
Inflammation 2 59.88 Quite High
Pain 9 44.56 Quite Low
Pain score 1 12.24 Low Low
antagonist 8 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Angioedema 111 87.04 High High
Disease 11 85.20 High High
Pressure And Volume Under Development 37 80.48 Quite High
INFLAMMATION 2 59.88 Quite High
Injury 2 59.20 Quite High
Infection 4 58.88 Quite High
Laryngeal Edema 3 54.88 Quite High
Emergencies 1 20.92 Low Low
Unconsciousness 1 17.32 Low Low
Shock 1 16.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C1-inh is also a major inhibitor of factor XII and kallikrein of the contact system, and to a lesser extent of factor XI and tissue-type plasminogen.
C1-inh Negative_regulation (inhibitor) of factor XII
1) Confidence 0.24 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2887436 Disease Relevance 0.71 Pain Relevance 0.04
In the contact system pathway, C1-inhibitor inactivates both factor XIIa and active kallikrein, thereby preventing both the activation of kallikrein from prekallikrein and the formation of bradykinin, a vascular permeability factor [2,20,21,23-25].
C1-inhibitor Negative_regulation (inactivates) of factor XIIa associated with bradykinin
2) Confidence 0.03 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.48 Pain Relevance 0.08

General Comments

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