INT232025

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Context Info
Confidence 0.56
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPING1) extracellular region (SERPING1)
Anatomy Link Frequency
plasma 2
SERPING1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 10 84.00 Quite High
bradykinin 46 36.24 Quite Low
antagonist 11 25.00 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Pain score 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hereditary Angioedema 190 98.62 Very High Very High Very High
Adverse Drug Reaction 3 84.72 Quite High
Pain 4 84.00 Quite High
Death 4 79.68 Quite High
Pressure And Volume Under Development 75 73.20 Quite High
Body Weight 7 52.08 Quite High
Disease 12 28.88 Quite Low
Targeted Disruption 6 25.00 Low Low
Laryngeal Edema 14 5.00 Very Low Very Low Very Low
Hepatitis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The condition is the result of a defect in the gene controlling the synthesis of C1-inhibitor, which regulates the activity of a number of plasma cascade systems.
Regulation (controlling) of Gene_expression (synthesis) of C1-inhibitor in plasma
1) Confidence 0.56 Published 2008 Journal Clin Mol Allergy Section Abstract Doc Link PMC2374835 Disease Relevance 0.79 Pain Relevance 0.15
Gadek et al demonstrated that C1-INH levels peaked rapidly and dropped quickly; however, C4 levels peaked approximately 6 hours after the C1-INH levels, and the C4 levels remained elevated for a much longer period of time.
Regulation (dropped) of Gene_expression (levels) of C1-INH
2) Confidence 0.44 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.63 Pain Relevance 0
Hereditary angioedema (HAE) is an autosomal dominant condition caused by mutations to the gene controlling C1-inhibitor production.
Regulation (controlling) of Gene_expression (production) of C1-inhibitor associated with hereditary angioedema
3) Confidence 0.25 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.33 Pain Relevance 0

General Comments

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