INT232069

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.60
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (RNPC3) RNA binding (RNPC3) nucleus (RNPC3)
Anatomy Link Frequency
nose 1
RNPC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 92.88 High High
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 73 96.92 Very High Very High Very High
INFLAMMATION 8 92.88 High High
Disease 7 56.80 Quite High
Sprains And Strains 24 51.76 Quite High
Weight Loss 10 19.80 Low Low
Infection 35 5.00 Very Low Very Low Very Low
Influenza In Birds 26 5.00 Very Low Very Low Very Low
Respiratory Syncytial Virus 6 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Lung Cancer 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the PB2-E627K mutation clearly carries great significance, it was insufficient to increase replication of an avian RNP-containing virus in human cell culture.
Positive_regulation (increase) of RNP
1) Confidence 0.13 Published 2010 Journal mBio Section Body Doc Link PMC2912665 Disease Relevance 0.28 Pain Relevance 0
These findings indicated that the increased mouse virulence attributed to avian PB1 in the WY03 genetic background (r1/3/5/7/8) may not directly result from stimulation of the polymerase activities of the RNP.
Positive_regulation (stimulation) of RNP
2) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0 Pain Relevance 0
In this study, a single mutation, PB2 D87N, was responsible for increased G2 RNP polymerase activity at the lower temperature (33°C) found in the mammalian airway and, therefore, probably contributed to better replication in the nose, significantly elevated inflammation, or more efficient transmission.
Positive_regulation (increased) of G2 RNP in nose associated with inflammation
3) Confidence 0.05 Published 2010 Journal mBio Section Body Doc Link PMC2993010 Disease Relevance 0.31 Pain Relevance 0.05

General Comments

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