INT232075

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (PBRM1) nuclear chromosome (PBRM1) nucleus (PBRM1)
DNA binding (PBRM1)
Anatomy Link Frequency
internal 1
A549 1
PBRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 6 98.76 Very High Very High Very High
Lung Cancer 9 93.82 High High
Influenza Virus Infection 84 80.96 Quite High
Infection 54 62.16 Quite High
Death 6 58.56 Quite High
Influenza In Birds 54 55.16 Quite High
Weight Loss 12 30.68 Quite Low
Body Weight 6 5.00 Very Low Very Low Very Low
Asymptomatic Infections 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A549 cells cultured in 24-well tissue culture plates were co-transfected with pPol1-NS-Renilla (100 ng) encoding a reporter mini-genome under transcriptional control of the human RNA polymerase I, pSV-Luc (200 ng) encoding firefly luciferase under SV40 virus RNA polymerase II promoter control, and four plasmids expressing viral PB2, PB1, PA, NP (50 ng each) from the strain of interest.
Gene_expression (expressing) of PB1 in A549 associated with lung cancer and sprains and strains
1) Confidence 0.50 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0.33 Pain Relevance 0
(In this report, the term “internal genes” refers to the gene constellation comprising PB2, PB1, PA, NP, M, and NS, although the M gene encodes for the M2 protein, which is surface-exposed in virions.)
Gene_expression (comprising) of PB1 in internal
2) Confidence 0.43 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0.42 Pain Relevance 0
Interestingly, the polymerase activity of the RNP with PB1 from TH04 and the other proteins from WY03 was comparable to that of the wt WY03 RNP.
Gene_expression (activity) of PB1
3) Confidence 0.38 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374906 Disease Relevance 0 Pain Relevance 0

General Comments

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