INT23209

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Context Info
Confidence 0.38
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 2.04
Pain Relevance 8.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Anatomy Link Frequency
neurons 2
forebrain 2
basal ganglia 1
brainstem 1
small intestine 1
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 358 100.00 Very High Very High Very High
agonist 207 100.00 Very High Very High Very High
Dopamine 23 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
headache 4 100.00 Very High Very High Very High
antagonist 86 99.96 Very High Very High Very High
Migraine 8 99.76 Very High Very High Very High
medulla 7 99.36 Very High Very High Very High
cocaine 13 99.30 Very High Very High Very High
opiate 4 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine With Aura 2 99.76 Very High Very High Very High
Disease 19 95.32 Very High Very High Very High
Nociception 1 95.28 Very High Very High Very High
Cv Unclassified Under Development 4 94.64 High High
Parkinson's Disease 2 93.76 High High
Headache 9 92.84 High High
Anxiety Disorder 8 88.28 High High
Epilepsy 5 83.20 Quite High
Neurological Disease 10 79.36 Quite High
Depression 9 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenosine A2A and dopamine receptor interactions in basal ganglia of dopamine denervated rats.
A2A Binding (interactions) of in basal ganglia associated with dopamine, adenocard and dopamine receptor
1) Confidence 0.38 Published 2003 Journal Neurology Section Title Doc Link 14663008 Disease Relevance 0.10 Pain Relevance 0.48
This binding increases more slowly than receptor number, suggesting that the appearance of G proteins, rather than the A2AR, determines the developmental appearance of functional A2AR-G protein interactions in forebrain.
A2AR Binding (interactions) of in forebrain
2) Confidence 0.37 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.30
In contrast, in hindbrain, A2AR-stimulated [35S]GTPgammaS binding decreases during postnatal development in parallel with the decrease in A2AR levels, whereas [35S]GTPgammaS binding stimulated by other neurotransmitter receptor systems increases in parallel with basal [35S]GTPgammaS binding.
A2AR Binding (binding) of in hindbrain associated with neurotransmitter
3) Confidence 0.35 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.35
Basal [35S]GTPgammaS binding and [35S]GTPgammaS binding stimulated by other neurotransmitter receptor systems (GABA-B, mu opiate, and muscarinic) increase with a time course similar to A2AR-stimulated [35S]GTPgammaS binding.
A2AR Binding (binding) of associated with gaba, neurotransmitter and opiate
4) Confidence 0.35 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.35
In forebrain the A2AR agonist-stimulated [35S]GTPgammaS binding increases rapidly after P7, reaching its highest levels at P21 and then declining slightly to adult levels.
A2AR Binding (binding) of in forebrain associated with agonist
5) Confidence 0.35 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027851 Disease Relevance 0 Pain Relevance 0.23
An adenosine A2A receptor gene haplotype is associated with migraine with aura.
adenosine A2A receptor Binding (associated) of associated with adenocard and migraine
6) Confidence 0.35 Published 2007 Journal Cephalalgia Section Title Doc Link 17257240 Disease Relevance 0.85 Pain Relevance 0.88
Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.
ADORA2A Binding (Association) of associated with headache
7) Confidence 0.34 Published 2010 Journal Neuropsychopharmacology Section Title Doc Link 20520601 Disease Relevance 0.34 Pain Relevance 0.27
No significant cocaine-induced change was found in A1 or A2A receptor binding in any region analyzed.
A2A receptor Binding (binding) of associated with cocaine
8) Confidence 0.33 Published 2005 Journal Synapse Section Abstract Doc Link 15945065 Disease Relevance 0.06 Pain Relevance 1.12
The long C terminus of the A2AR has been coined a ‘coincidence detectorÂ’ as it recognizes quite a number of other proteins such as ?
A2AR Binding (recognizes) of
9) Confidence 0.31 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.20
While A1Rs communicate mainly with the D1R subtype in strionigral-strioentopenduncular neurons, A2AR and D2R interaction occurs in striopallidal neurons.
A2AR Binding (interaction) of in neurons
10) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.23 Pain Relevance 0.55
Interactions with metabotropic dopamine receptors as well as A2A, A3, NPY, and P2Y1 receptors will be described in the first part.
A2A Binding (Interactions) of associated with dopamine receptor
11) Confidence 0.25 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.15 Pain Relevance 0.42
Herein, the prototypic antidepressant, imipramine (IMI), has been studied in regard to its treatment effects on [125I]p-iodoclonidine binding to both alpha 2 AR and IR1 in rat brainstem membranes.
alpha 2 AR Binding (binding) of in brainstem associated with medulla and antidepressant
12) Confidence 0.18 Published 1997 Journal Life Sci. Section Abstract Doc Link 9364202 Disease Relevance 0 Pain Relevance 0.44
Using either ligand binding, functional studies, or molecular techniques, A1, A2A, A2B, and A3 receptors have been identified within the rat small intestine [7-10].
A2A Binding (binding) of in small intestine
13) Confidence 0.15 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.37
These results suggest that the noradrenergic component of the supra-additive interaction between adenosine A2 receptor agonists and noradrenergic agonists is mediated by alpha 2 noradrenergic receptors.
adenosine A2 receptor Binding (interaction) of associated with adenocard and agonist
14) Confidence 0.15 Published 1990 Journal Brain Res. Section Abstract Doc Link 2397411 Disease Relevance 0.19 Pain Relevance 1.30
In control membranes alpha1AR stimulation increased [35S]GTPgammaS binding to Galphaq and Galphai proteins, whereas the alpha2AR agonist UK14,304 activated [35S]GTPgammaS binding to Galphai exclusively.
alpha2AR Binding (binding) of associated with agonist
15) Confidence 0.02 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.21
In support, caffeine acts as an AD receptor antagonist, binds to the A1 and A2A receptors [49], but exerts its arousal effect mainly via the latter [135].
A2A Binding (binds) of associated with adenocard and antagonist
16) Confidence 0.01 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.13 Pain Relevance 0.54
In the striatum, adenosine A2A and dopamine D2 receptors exert reciprocal antagonistic interactions that modulate the function of GABAergic enkephalinergic neurons.
adenosine A2A Binding (interactions) of in neurons associated with dopamine, adenocard and gabaergic
17) Confidence 0.01 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16452987 Disease Relevance 0 Pain Relevance 0.35

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