INT232187

Context Info Confidence 0.06 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.32 Pain Relevance 0.29

cilium (DFNB31) cytoplasm (DFNB31)

Anatomy Link Frequency fibroblasts 1 DFNB31 (Homo sapiens)

Pain Link Frequency Relevance Heat postherpetic neuralgia 20 75.08 Pain 27 50.56 Shingles 9 50.00 corticosteroid 5 5.00 Analgesic 3 5.00 Gabapentin 3 5.00 Dermatone 2 5.00 intrathecal 2 5.00 Pain score 2 5.00 tricyclic antidepressant 2 5.00

Disease Link Frequency Relevance Heat Herpes Zoster 159 99.36 Disease 4 90.64 Post Operative Pain 20 75.08 Infection 6 59.76 Exanthema 9 52.36 Pain 31 50.56 Acquired Immune Deficiency Syndrome Or Hiv Infection 2 29.12 Cancer 1 26.20 Organ Transplantation 1 10.80 Measles 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Merck laboratories passaged the virus further though different cell lines including HEL, GPE, WI-38, and MRC-5 human diploid fibroblasts to produce the commercial varicella vaccine (Varivax) which contains 1350 PFUs in 0.5 ml of sterile water (Ellis 1995).

Gene_expression (produce) of WI-38 in fibroblasts associated with herpes zoster

1) Confidence 0.06 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374947 Disease Relevance 1.32 Pain Relevance 0.29

General Comments

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