INT23220

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 16
Disease Relevance 2.86
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FOXG1) DNA binding (FOXG1) transcription factor binding (FOXG1)
Anatomy Link Frequency
juvenile 1
sympathetic 1
hindlimb 1
tooth pulp 1
FOXG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
isoflurane 10 99.98 Very High Very High Very High
anesthesia 12 98.90 Very High Very High Very High
adenocard 4 98.60 Very High Very High Very High
halothane 10 98.36 Very High Very High Very High
Spinal cord 5 94.68 High High
cINOD 2 89.00 High High
antagonist 7 83.36 Quite High
substance P 2 78.76 Quite High
qutenza 10 73.04 Quite High
Pain 10 72.32 Quite High
Disease Link Frequency Relevance Heat
Juvenile Myelomonocytic Leukemia 1 99.60 Very High Very High Very High
Anaemia 25 99.34 Very High Very High Very High
Sideroblastic Anemia 3 98.58 Very High Very High Very High
Hemoglobinopathy 19 98.40 Very High Very High Very High
Aplastic Anemia 2 98.12 Very High Very High Very High
Pressure And Volume Under Development 3 97.80 Very High Very High Very High
Thalassemia 193 91.12 High High
INFLAMMATION 3 88.76 High High
Iron Overload 33 78.88 Quite High
Bartter Syndrome 2 76.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the increase of HBF in response to hindlimb pinching was dependent on the increase in blood pressure, and was not influenced by the severance of hepatic sympathetic nerves, and the responses to hindlimb pinching were almost absent after the spinal cord was transected.
Positive_regulation (increase) of HBF in sympathetic associated with pressure and volume under development and spinal cord
1) Confidence 0.43 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12171255 Disease Relevance 0.10 Pain Relevance 0.09
Pinching of the abdomen decreased, while pinching of the hindlimb increased the HBF.
Positive_regulation (increased) of HBF in hindlimb
2) Confidence 0.29 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12171255 Disease Relevance 0.08 Pain Relevance 0.08
We conclude that isoflurane increases HBF in anesthetized patients and is associated with a higher hepatic venous oxygen saturation than is halothane.
Positive_regulation (increases) of HBF associated with halothane and isoflurane
3) Confidence 0.27 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2400117 Disease Relevance 0 Pain Relevance 0.94
During anesthesia cardiac index remained stable in both groups, whereas HBF increased significantly with isoflurane but did not change significantly with halothane.
Neg (not) Positive_regulation (increased) of HBF associated with anesthesia, halothane and isoflurane
4) Confidence 0.27 Published 1990 Journal Anesth. Analg. Section Abstract Doc Link 2400117 Disease Relevance 0 Pain Relevance 0.94
The level of SAP six weeks after THA gradually increased with the amount of HBF.
Positive_regulation (increased) of HBF
5) Confidence 0.03 Published 1988 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 3136963 Disease Relevance 0.09 Pain Relevance 0.16
In sensory-denervated rats the resting HBF and PBF were increased by 23% (p< 0.05) and 34% (p< 0.05), respectively in comparison to the control HBF and PBF values.
Positive_regulation (increased) of HBF
6) Confidence 0.02 Published 2005 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15795481 Disease Relevance 0 Pain Relevance 0.52
In sensory-denervated rats the resting HBF and PBF were increased by 23% (p< 0.05) and 34% (p< 0.05), respectively in comparison to the control HBF and PBF values.
Positive_regulation (increased) of HBF
7) Confidence 0.02 Published 2005 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15795481 Disease Relevance 0 Pain Relevance 0.46
In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors.
Spec (whether) Positive_regulation (increase) of HBF in tooth pulp associated with adenocard
8) Confidence 0.02 Published 2009 Journal Neurosci. Res. Section Abstract Doc Link 19559058 Disease Relevance 0 Pain Relevance 0.16
1B (Qin et al., 2003) subunits are generated by splice variants of SCN1B. mRNA transcripts encoding for these ?
Positive_regulation (generated) of Qin
9) Confidence 0.02 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0.25 Pain Relevance 0
The ability of S110 to induce HbF in vivo appears to be comparable to that of decitabine.
Positive_regulation (induce) of HbF
10) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2958909 Disease Relevance 0.13 Pain Relevance 0
S110 increased HbF and reduced DNA methylation of the ?
Positive_regulation (increased) of HbF
11) Confidence 0.02 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2958909 Disease Relevance 0.08 Pain Relevance 0
The mechanism responsible for increased HbF by DNMT inhibitors is a matter of current controversy, however [17,18].
Positive_regulation (increased) of HbF
12) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2958909 Disease Relevance 0.17 Pain Relevance 0
Induction of HbF occurred following administration of both S110 and decitabine.
Positive_regulation (Induction) of HbF
13) Confidence 0.02 Published 2010 Journal J Transl Med Section Body Doc Link PMC2958909 Disease Relevance 0 Pain Relevance 0
A potential therapeutic role for S110 is to increase fetal hemoglobin (HbF) levels to treat ?
Positive_regulation (increase) of HbF
14) Confidence 0.02 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2958909 Disease Relevance 0.10 Pain Relevance 0
S110 is rapidly converted into decitabine, hypomethylates DNA, and induces HbF in cultured human erythroid progenitors and the baboon pre-clinical model.



Positive_regulation (induces) of HbF
15) Confidence 0.02 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2958909 Disease Relevance 0.07 Pain Relevance 0
Differential diagnosis is usually straightforward but may include genetic sideroblastic anemias, congenital dyserythropoietic anemias, and other conditions with high levels of HbF (such as juvenile myelomonocytic leukemia and aplastic anemia).
Positive_regulation (levels) of HbF in juvenile associated with juvenile myelomonocytic leukemia, aplastic anemia, anaemia and sideroblastic anemia
16) Confidence 0.01 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2893117 Disease Relevance 1.81 Pain Relevance 0.12

General Comments

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