INT23222

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Context Info
Confidence 0.31
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 52
Total Number 55
Disease Relevance 7.61
Pain Relevance 30.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Phax) RNA binding (Phax) nucleus (Phax)
cytoplasm (Phax)
Anatomy Link Frequency
spinal cord 6
dorsal root ganglia 4
brain 2
TM3 2
cerebellum 1
Phax (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 118 100.00 Very High Very High Very High
agonist 77 100.00 Very High Very High Very High
qutenza 588 99.84 Very High Very High Very High
Spinal cord 156 99.68 Very High Very High Very High
Analgesic 45 99.52 Very High Very High Very High
Potency 21 99.44 Very High Very High Very High
Kinase C 16 99.16 Very High Very High Very High
Locus ceruleus 19 99.08 Very High Very High Very High
depression 27 99.04 Very High Very High Very High
c fibre 148 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 130 100.00 Very High Very High Very High
Depression 19 99.04 Very High Very High Very High
Stress Incontinence 8 98.96 Very High Very High Very High
Increased Venous Pressure Under Development 17 98.76 Very High Very High Very High
Toxicity 14 98.72 Very High Very High Very High
INFLAMMATION 209 97.88 Very High Very High Very High
Infection 13 97.44 Very High Very High Very High
Ganglion Cysts 137 97.30 Very High Very High Very High
Neuropathic Pain 20 96.84 Very High Very High Very High
Injury 14 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Computer fitting of the binding data yielded Hill coefficient values of 2.25 +/- 0.03, 2.33 +/- 0.03, and 1.84 +/- 0.05 for RTX, RTX-amide, and phorbol 12,13-dibenzoate 20-homovanillylamide, respectively, indicating that both new compounds induced apparent positive cooperativity among vanilloid binding sites.
RTX Binding (binding) of
1) Confidence 0.31 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790875 Disease Relevance 0 Pain Relevance 0.43
Computer fitting of the binding data yielded Hill coefficient values of 2.25 +/- 0.03, 2.33 +/- 0.03, and 1.84 +/- 0.05 for RTX, RTX-amide, and phorbol 12,13-dibenzoate 20-homovanillylamide, respectively, indicating that both new compounds induced apparent positive cooperativity among vanilloid binding sites.
RTX Binding (binding) of
2) Confidence 0.31 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790875 Disease Relevance 0 Pain Relevance 0.43
Computer fitting of the binding data yielded Hill coefficient values of 2.25 +/- 0.03, 2.33 +/- 0.03, and 1.84 +/- 0.05 for RTX, RTX-amide, and phorbol 12,13-dibenzoate 20-homovanillylamide, respectively, indicating that both new compounds induced apparent positive cooperativity among vanilloid binding sites.
RTX Binding (binding) of
3) Confidence 0.31 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7790875 Disease Relevance 0 Pain Relevance 0.43
However, no detectable specific [3H]RTX binding was present in membranes of brain nuclei from rats pretreated with 300 mg/kg capsaicin, a treatment which causes loss of response to capsaicin.
RTX Binding (binding) of in brain associated with qutenza
4) Confidence 0.31 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.62
The corresponding levels of specific [3H]RTX binding in the preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus were 44.9 +/- 2.4, 50.6 +/- 3.0, 36.1 +/- 2.9, 9.4 +/- 2.8 and 8.4 +/- 2.4 fmol/mg, respectively.
RTX Binding (binding) of in preoptic area associated with locus ceruleus and thalamus
5) Confidence 0.31 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.58
Significant specific [3H]RTX binding was also absent in membrane preparations of the midbrain central gray matter, somatosensory cortex and cerebellum either from naive or capsaicin treated rats.
RTX Binding (binding) of in cerebellum associated with somatosensory cortex, qutenza and midbrain
6) Confidence 0.31 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.66
The determined levels of binding at 4 nM [3H]RTX were 23.0 +/- 4.5, 7.1 +/- 1.6, 29.9 +/- 2.3, 23.5 +/- 2.4, 9.9 +/- 2.2 and 8.1 +/- 1.9 fmol/mg, respectively; unfortunately, the high levels of non-specific binding (higher than 80%) in the present experiments made it impossible for us to characterize fully the binding properties of the receptors.
RTX Spec (determined) Binding (binding) of
7) Confidence 0.31 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.43
Specific high-affinity binding of [3H]RTX could be detected in membrane preparations of the posterior ("hypothalamic") and anterior ("septal") parts of the preoptic area, locus ceruleus, medial hypothalamus, brainstem reticular formation and ventral thalamic nuclei from naive rats.
RTX Binding (binding) of in medial associated with medulla and locus ceruleus
8) Confidence 0.31 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.26
The same difference was observed when comparing the inhibition of [3H]RTX binding to rat and human TRPV1 membranes for both RTX and I-RTX.
RTX Binding (comparing) of
9) Confidence 0.29 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438527 Disease Relevance 0.08 Pain Relevance 0.38
The same difference was observed when comparing the inhibition of [3H]RTX binding to rat and human TRPV1 membranes for both RTX and I-RTX.
RTX Binding (comparing) of
10) Confidence 0.25 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438527 Disease Relevance 0.08 Pain Relevance 0.38
Thus, the in vivo expression of vanilloid receptors detected by specific [3H]RTX binding does not require the presence of intraaxonally transported trophic factors such as nerve growth factor.
RTX Binding (binding) of in nerve associated with nerve growth factor
11) Confidence 0.23 Published 1996 Journal Brain Res. Section Abstract Doc Link 8782884 Disease Relevance 0.19 Pain Relevance 0.30
Resiniferatoxin also caused direct activation of a Ca(2+)- and lipid-dependent kinase (or kinases) in the cytosolic fraction of dorsal root ganglia, at concentrations (100 nM to 10 microM) higher than required for displacement of [3H]resiniferatoxin binding or translocation of protein kinase C.
resiniferatoxin Binding (binding) of in dorsal root ganglia associated with kinase c
12) Confidence 0.23 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.17 Pain Relevance 0.74
Specific [3H]-resiniferatoxin binding, which was detected in the membrane (KD value 1.8 +/- 0.2 nM) but not cytosolic fraction of rat dorsal root ganglia, could not be displaced by phorbol 12,13-dibutyrate.
resiniferatoxin Binding (binding) of in dorsal root ganglia
13) Confidence 0.23 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643108 Disease Relevance 0.07 Pain Relevance 0.55
Consistent with this difference, in C6 cells we were unable to detect [3H]RTX binding.
RTX Binding (binding) of
14) Confidence 0.20 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602075 Disease Relevance 0.31 Pain Relevance 0.83
Application of RTX initially evokes nociceptive activity by binding to and activating TRPV1 [14].
RTX Binding (binding) of associated with nociception
15) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.29 Pain Relevance 0.27
Likewise, the competitive antagonist capsazepine inhibited RTX-induced desensitization with potency similar to that for inhibition of specific [3H]RTX binding, whereas the potency of capsazepine was approximately 10-fold higher for inhibiting RTX-induced 45Ca uptake.
RTX Binding (binding) of associated with antagonist and potency
16) Confidence 0.12 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9204943 Disease Relevance 0.29 Pain Relevance 0.61
The RTX-induced desensitization was not associated with loss of specific [3H]RTX binding, suggesting lack of gross cell toxicity.
RTX Binding (binding) of associated with toxicity
17) Confidence 0.12 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9204943 Disease Relevance 0.28 Pain Relevance 0.68
In the present study, we have demonstrated that the ultrapotent capsaicin analog resiniferatoxin (RTX) desensitized rat DRG neurons to the subsequent induction of 45Ca uptake by capsaicin and RTX with affinity and cooperativity similar to that found for [3H]RTX binding, contrasting with a approximately 10-fold weaker potency and lack of cooperativity to induce 45Ca uptake.
RTX Binding (binding) of in neurons associated with dorsal root ganglion, qutenza and potency
18) Confidence 0.12 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9204943 Disease Relevance 0.26 Pain Relevance 0.53
Significant specific [3H]RTX binding was also absent in membrane preparations of the midbrain central gray matter, somatosensory cortex and cerebellum either from naive or capsaicin treated rats.
RTX Binding (binding) of in cortex associated with somatosensory cortex, qutenza and midbrain
19) Confidence 0.11 Published 1996 Journal Life Sci. Section Abstract Doc Link 8950287 Disease Relevance 0 Pain Relevance 0.66
The results also demonstrate that mid-plantar injection of RTX removes both A?
RTX Binding (injection) of
20) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.23 Pain Relevance 0.33

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