INT232235

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.13
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
plasma 2
hepatocytes 2
adipose tissue 2
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 135 96.80 Very High Very High Very High
Catecholamine 12 85.68 High High
Inflammatory response 19 35.52 Quite Low
noradrenaline 14 13.20 Low Low
Bile 21 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 83 99.88 Very High Very High Very High
Metabolic Syndrome 6 98.88 Very High Very High Very High
Disorder Of Lipid Metabolism 95 98.48 Very High Very High Very High
Stress 112 96.80 Very High Very High Very High
Atherosclerosis 87 92.84 High High
INFLAMMATION 94 90.76 High High
Hyperlipoproteinemia Type Ii 198 88.32 High High
Cytomegalovirus Infection 21 87.00 High High
Aggression 3 83.68 Quite High
Infection 27 80.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings suggest that decreased LDL concentrations in the microcirculation of adipose tissue cause a reciprocal activation of lipolysis in white adipose tissue when apoB100-LDL levels are decreased.
Negative_regulation (decreased) of Gene_expression (levels) of apoB100-LDL in adipose tissue associated with obesity
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.86 Pain Relevance 0.11
The loss of hLDLR expression in non anti-CD154-treated mice also demonstrated the importance of the host immune response against vector and transgene products [137].
Negative_regulation (loss) of Gene_expression (expression) of hLDLR
2) Confidence 0.34 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.17 Pain Relevance 0
However, the high level of LDLR expression and substantial reduction of total and LDL cholesterol achieved by adenovirus LDLR gene transfer in these animal models led to a massive intracellular lipid (cholesterol and cholesterol ester) deposition in transduced cells [130,133].
Negative_regulation (reduction) of Gene_expression (expression) of LDLR
3) Confidence 0.34 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.45 Pain Relevance 0
Liver biopsies performed four months after treatment revealed LDLR transgene expression in a limited number of hepatocytes by in situ hybridisation in all four subjects.
Negative_regulation (revealed) of Gene_expression (expression) of LDLR in hepatocytes
4) Confidence 0.34 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.35 Pain Relevance 0
For example, the expression of genes involved in endogenous cholesterol synthesis (for example, HMG-CoA reductase) and cholesterol uptake from plasma (for example, LDLR) is diminished.
Negative_regulation (diminished) of Gene_expression (expression) of LDLR in plasma
5) Confidence 0.31 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.31 Pain Relevance 0.23

General Comments

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