INT23225

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Context Info
Confidence 0.34
First Reported 1988
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.66
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocyte 2
brain stem 2
thoracic 2
heart 2
tf (Mus musculus)
Pain Link Frequency Relevance Heat
tail-flick 40 100.00 Very High Very High Very High
cytokine 5 100.00 Very High Very High Very High
amygdala 9 99.84 Very High Very High Very High
Rostral ventromedial medulla 10 99.72 Very High Very High Very High
Spinal cord 5 99.30 Very High Very High Very High
gABA 4 97.88 Very High Very High Very High
Angina 6 96.52 Very High Very High Very High
antagonist 1 95.20 Very High Very High Very High
lidocaine 7 94.72 High High
midbrain 2 93.20 High High
Disease Link Frequency Relevance Heat
Nociception 8 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 137 99.84 Very High Very High Very High
Spinal Cord Injury 2 99.54 Very High Very High Very High
Sleep Disorders 4 99.16 Very High Very High Very High
Cv Unclassified Under Development 4 96.68 Very High Very High Very High
Cv General 3 Under Development 6 96.52 Very High Very High Very High
Hypotension 6 89.12 High High
Adhesions 18 88.16 High High
Pressure Volume 2 Under Development 2 82.64 Quite High
Urological Neuroanatomy 11 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, low thoracic spinal cord transection (T9-10) abolished the inhibition of the TF reflex produced by i.v. 5-HT.
Negative_regulation (inhibition) of Gene_expression (produced) of TF in thoracic associated with tail-flick and spinal cord
1) Confidence 0.34 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.53 Pain Relevance 0.46
Prevention of 5-HT-induced reflex apnea by artificial ventilation did not affect inhibition of the TF reflex produced by 5-HT.
Negative_regulation (inhibition) of Gene_expression (produced) of TF associated with tail-flick and sleep disorders
2) Confidence 0.34 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.79 Pain Relevance 0.29
TF synthesis stimulated by VLDL is rather inhibited by HDL (Rosenson and Lowe 1998).
Negative_regulation (inhibited) of Gene_expression (synthesis) of TF associated with disorder of lipid metabolism
3) Confidence 0.12 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.18 Pain Relevance 0
A smaller dose (100 ng) of bicuculline enhanced the inhibition of TF reflex produced by 5-HT application into Sm, whereas application of GABA (2.5 microg) did not influence the TF reflex but significantly attenuated the 5-HT-evoked inhibition.
Negative_regulation (inhibition) of Gene_expression (produced) of TF associated with gaba and tail-flick
4) Confidence 0.05 Published 2005 Journal Brain Res. Section Abstract Doc Link 16125153 Disease Relevance 0.23 Pain Relevance 1.02
In in vitro experiments heparin is able to blunt monocyte TF production by inhibiting TF and cytokine gene expression by stimulated cells and after in vivo administration it reduces adverse ischemic outcomes in UA patients.
Negative_regulation (inhibiting) of Gene_expression (expression) of TF in monocyte associated with angina and cytokine
5) Confidence 0.04 Published 1999 Journal Thromb. Haemost. Section Abstract Doc Link 10235445 Disease Relevance 0.37 Pain Relevance 0.42
Chronic RVM lesions also blocked TF inhibition produced by amygdala stimulation but did not affect heart rate.
Negative_regulation (blocked) of Gene_expression (produced) of TF in heart associated with tail-flick, amygdala and rostral ventromedial medulla
6) Confidence 0.04 Published 1998 Journal Brain Res. Section Abstract Doc Link 9473612 Disease Relevance 0.40 Pain Relevance 2.08
The present study, in rats lightly anesthetized with pentobarbital, was undertaken to examine systematically the organization in the brain stem of pathways mediating descending inhibition of the nociceptive tail flick (TF) reflex produced by focal electrical stimulation in the LH.
Negative_regulation (inhibition) of Gene_expression (produced) of TF in brain stem associated with nociception and tail-flick
7) Confidence 0.03 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 3249250 Disease Relevance 0.16 Pain Relevance 0.59

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