INT23226

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Context Info
Confidence 0.43
First Reported 1986
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 31
Disease Relevance 15.55
Pain Relevance 14.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 5
EM-2 2
blood 2
blood cells 2
tail 1
tf (Mus musculus)
Pain Link Frequency Relevance Heat
tail-flick 45 100.00 Very High Very High Very High
Morphine 19 100.00 Very High Very High Very High
Pain threshold 1 100.00 Very High Very High Very High
analgesia 6 99.82 Very High Very High Very High
ketamine 8 99.70 Very High Very High Very High
Inflammation 121 99.68 Very High Very High Very High
intrathecal 7 99.52 Very High Very High Very High
electroacupuncture 10 99.36 Very High Very High Very High
agonist 84 99.32 Very High Very High Very High
cINOD 4 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
Hemolytic Uremic Syndrome 369 99.68 Very High Very High Very High
INFLAMMATION 150 99.68 Very High Very High Very High
Acute Coronary Syndrome 24 99.68 Very High Very High Very High
Endotoxemia 36 99.32 Very High Very High Very High
Coagulation Disorder 21 99.28 Very High Very High Very High
Disease 62 98.92 Very High Very High Very High
Cv General 3 Under Development 50 98.68 Very High Very High Very High
Pressure Volume 2 Under Development 4 96.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs produced a statistically significant increase in pain threshold for CD, but not for TF.
Positive_regulation (increase) of TF associated with pain threshold, tail-flick and cinod
1) Confidence 0.43 Published 1994 Journal Masui Section Abstract Doc Link 7967024 Disease Relevance 0.35 Pain Relevance 1.48
The EM-2-induced antianalgesic effect against morphine-induced TF inhibition was blocked by i.t. pretreatment with antiserum against dynorphin A(1-17), but not beta-endorphin, [Met]-enkephalin, [Leu]-enkephalin, or cholecystokinin antiserum (200 microg each).
Positive_regulation (morphine-induced) of TF in EM-2 associated with dynorphin, tail-flick, enkephalin, cholecystokinin and morphine
2) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 2.21
The EM-2 (1.75 nmol)-produced anti-analgesia against morphine-induced TF inhibition was blocked by i.t. pretreatment with the mu-opioid antagonist naloxone or 3-methoxynaltrexone, but not delta-opioid receptor antagonist naltrindole, kappa-opioid receptor antagonist nor-binaltorphimine, or N-methyl-d-aspartate (NMDA) receptor antagonist MK-801.
Positive_regulation (morphine-induced) of TF in EM-2 associated with kappa opioid receptor, narcan, tail-flick, opioid receptor, morphine, analgesia, antagonist and opioid
3) Confidence 0.42 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 1.98
It is known that activation of TF can trigger a pro-coagulation status, and lead to fibrin deposition in the lung.
Positive_regulation (activation) of TF in lung
4) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.05 Pain Relevance 0.10
Nitroprusside (8 micrograms/kg, i.v.) produced a decrease in blood pressure of similar magnitude and rate as that associated with the Bezold-Jarisch reflex-induced decrease in pressure produced by 72 micrograms/kg 5-HT, but did not change TF latency from baseline.
Neg (not) Positive_regulation (change) of TF in blood associated with pressure volume 2 under development and tail-flick
5) Confidence 0.37 Published 1990 Journal Brain Res. Section Abstract Doc Link 2400935 Disease Relevance 0.87 Pain Relevance 0.33
This pro-thrombotic pathway, ultimately generating thrombin, is operational during HUS as it has been shown that TF is elevated during HUS [17].
Positive_regulation (elevated) of TF associated with hemolytic uremic syndrome
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 1.04 Pain Relevance 0
RESULTS: The results show doctors who had previously prescribed TF are more confident and knowledgeable about the indications and pharmacology of TF than doctors who had never prescribed TF.
Positive_regulation (prescribed) of TF
7) Confidence 0.31 Published 2005 Journal Palliat Med Section Body Doc Link 15690863 Disease Relevance 0 Pain Relevance 0
The requirement of TF as a co-receptor for PAR1 and PAR2 activation is likely to be a key determinant [37].
Positive_regulation (requirement) of TF
8) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 0.70 Pain Relevance 0.20
Concomitant with the increase in TF latency, the TF-related deceleration of the off-cells and acceleration of the on-cells were reduced.
Positive_regulation (increase) of TF
9) Confidence 0.28 Published 1986 Journal Brain Res. Section Abstract Doc Link 3801864 Disease Relevance 0.50 Pain Relevance 0.80
The TF expression and activity in lung alveolar epithelial cells was increased by pro-inflammatory cytokines (e.g.
Positive_regulation (increased) of TF in epithelial cells associated with inflammation and cytokine
10) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2211395 Disease Relevance 1.07 Pain Relevance 0.10
All agonists tested, alone or in combination, induced increased plasma levels of functional TF, with a minimal additive effect when agonists were combined (Table 3).
Positive_regulation (induced) of TF in plasma associated with agonist
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.17 Pain Relevance 0.15
All agonists tested, alone or in combination, induced increased plasma levels of functional TF, with a minimal additive effect when agonists were combined (Table 3).
Positive_regulation (increased) of TF in plasma associated with agonist
12) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.16 Pain Relevance 0.15
RESULTS: The results show doctors who had previously prescribed TF are more confident and knowledgeable about the indications and pharmacology of TF than doctors who had never prescribed TF.
Positive_regulation (prescribed) of TF
13) Confidence 0.27 Published 2005 Journal Palliat Med Section Body Doc Link 15690863 Disease Relevance 0 Pain Relevance 0
TF-expressing microparticles were elevated during the acute phase of disease.


Positive_regulation (elevated) of TF associated with disease
14) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.66 Pain Relevance 0
The mechanism by which TF elevation in the circulation occurs in HUS has not been previously studied.
Positive_regulation (elevation) of TF associated with hemolytic uremic syndrome
15) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.79 Pain Relevance 0
TF is a transmembrane cell surface glycoprotein that acts as a receptor for coagulation factor VII/VIIa, catalyzes the conversion of factor X to the active form Xa and ultimately leads to thrombin formation.
Positive_regulation (acts) of TF
16) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.98 Pain Relevance 0.16
The interaction between these virulence factors and blood cells under shear flow allows blood cell aggregate formation and decryption of TF [48], expression of active TF on cell membranes as well as secretion of TF-rich microparticles.
Positive_regulation (active) of TF in blood cell
17) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.38 Pain Relevance 0.05
This top-down approach started by selecting a candidate TF out of 345 different TF consensus sequences present in a protein/DNA combo array (Panomics).
Positive_regulation (selecting) of TF
18) Confidence 0.19 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.51 Pain Relevance 0.33
TF–expressing microparticles, and functional TF in plasma, increased when blood cells were simultaneously exposed to the EHEC virulence factors and high shear stress.
Positive_regulation (increased) of TF in blood cells associated with stress
19) Confidence 0.18 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2735777 Disease Relevance 0.43 Pain Relevance 0
Furthermore, TF is elevated during systemic endotoxemia [51].
Positive_regulation (elevated) of TF associated with endotoxemia
20) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.80 Pain Relevance 0

General Comments

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