INT23229

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Context Info
Confidence 0.04
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.87
Pain Relevance 8.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 6
kidney 2
H2-M3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 118 100.00 Very High Very High Very High
tricyclic antidepressant 4 99.96 Very High Very High Very High
addiction 2 98.80 Very High Very High Very High
palliative 1 95.68 Very High Very High Very High
Opioid 2 90.64 High High
Cancer pain 8 77.60 Quite High
Bioavailability 1 75.00 Quite High
Inflammation 1 58.72 Quite High
Eae 2 33.84 Quite Low
Pain 12 25.00 Low Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 98.80 Very High Very High Very High
Vomiting 4 97.84 Very High Very High Very High
Cognitive Disorder 1 96.88 Very High Very High Very High
Hepatotoxicity 4 90.28 High High
Renal Failure 10 79.36 Quite High
Delirium 1 79.28 Quite High
Cancer Pain 8 77.60 Quite High
INFLAMMATION 1 58.72 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Chronic Renal Failure 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both morphine-3-glucuronid (M3G) and morphine-6-glucuronid (M6G) are rapidly formed in high concentrations shortly after heroin and morphine consumption.
Positive_regulation (formed) of M3G associated with morphine
1) Confidence 0.04 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18555521 Disease Relevance 0.10 Pain Relevance 0.76
M3G gradually increased after the morphine injection, peaked about 2 days later, then gradually decreased.
Positive_regulation (increased) of M3G associated with morphine
2) Confidence 0.04 Published 2008 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 18307503 Disease Relevance 0 Pain Relevance 1.02
Combined loss of Mrp2 and Mrp3 leads to a substantial accumulation of M3G in the liver, from which it is transported across the sinusoidal membrane at a low rate, resulting in the prolonged presence of M3G in plasma.
Positive_regulation (accumulation) of M3G in plasma
3) Confidence 0.03 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485564 Disease Relevance 0 Pain Relevance 0.25
Therefore the accumulation of M6G and M3G is readily explained by kidney failure which is not compensated by CAPD.
Positive_regulation (accumulation) of M3G in kidney
4) Confidence 0.01 Published 1999 Journal Nephrol. Dial. Transplant. Section Body Doc Link 10328468 Disease Relevance 0.12 Pain Relevance 0
RESULTS: While systemic clearance of morphine (1246+/-240 ml/min) was in the range observed in patients with normal kidney function, both M3G and M6G showed substantial accumulation.
Positive_regulation (accumulation) of M3G in kidney
5) Confidence 0.01 Published 1999 Journal Nephrol. Dial. Transplant. Section Body Doc Link 10328468 Disease Relevance 0.16 Pain Relevance 0
Other significant factors were: age greater than 70 years (increased M3G and M6G plasma concentrations), plasma creatinine greater than 150 mumol/L (increased M3G and M6G plasma concentrations), male sex (decreased morphine and M6G plasma concentrations), raised creatinine plus coadministration of tricyclic antidepressants (increased M3G plasma concentrations), ranitidine (increased morphine plasma concentrations), and raised creatinine plus coadministration of ranitidine (increased M6G plasma concentrations).
Positive_regulation (increased) of M3G in plasma associated with tricyclic antidepressant and morphine
6) Confidence 0.01 Published 1990 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2401122 Disease Relevance 0.23 Pain Relevance 1.28
Other significant factors were: age greater than 70 years (increased M3G and M6G plasma concentrations), plasma creatinine greater than 150 mumol/L (increased M3G and M6G plasma concentrations), male sex (decreased morphine and M6G plasma concentrations), raised creatinine plus coadministration of tricyclic antidepressants (increased M3G plasma concentrations), ranitidine (increased morphine plasma concentrations), and raised creatinine plus coadministration of ranitidine (increased M6G plasma concentrations).
Positive_regulation (increased) of M3G in plasma associated with tricyclic antidepressant and morphine
7) Confidence 0.01 Published 1990 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2401122 Disease Relevance 0.23 Pain Relevance 1.30
Increasing morphine dose was a significant factor for increased plasma concentrations of morphine, M3G, and M6G.
Positive_regulation (increased) of M3G in plasma associated with morphine
8) Confidence 0.01 Published 1990 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2401122 Disease Relevance 0.24 Pain Relevance 1.31
Other significant factors were: age greater than 70 years (increased M3G and M6G plasma concentrations), plasma creatinine greater than 150 mumol/L (increased M3G and M6G plasma concentrations), male sex (decreased morphine and M6G plasma concentrations), raised creatinine plus coadministration of tricyclic antidepressants (increased M3G plasma concentrations), ranitidine (increased morphine plasma concentrations), and raised creatinine plus coadministration of ranitidine (increased M6G plasma concentrations).
Positive_regulation (increased) of M3G in plasma associated with tricyclic antidepressant and morphine
9) Confidence 0.01 Published 1990 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2401122 Disease Relevance 0.21 Pain Relevance 1.22
In SOP, but not ROP, rabbits, the plasma concentrations of morphine, M3G and M6G were significantly increased compared with those in normal rabbits.
Positive_regulation (increased) of M3G in plasma associated with morphine
10) Confidence 0.00 Published 2003 Journal Int J Pharm Section Abstract Doc Link 14522119 Disease Relevance 0.06 Pain Relevance 0.83
The data indicate that accumulation of M3G and M6G may be a causal or aggravating factor in the nausea and vomiting and cognitive function profile of palliative and terminal care patients with significant renal function impairment.
Positive_regulation (accumulation) of M3G associated with cognitive disorder, vomiting and palliative
11) Confidence 0.00 Published 1997 Journal J Pain Symptom Manage Section Abstract Doc Link 9291702 Disease Relevance 0.53 Pain Relevance 0.58

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