INT2323

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2010
Negated 6
Speculated 0
Reported most in Abstract
Documents 146
Total Number 160
Disease Relevance 29.92
Pain Relevance 49.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
neurons 12
brain 9
striatum 7
nucleus 5
spinal cord 4
Trh (Rattus norvegicus)
Trh - T373K (1)
Pain Link Frequency Relevance Heat
Dopamine 1027 100.00 Very High Very High Very High
substance P 161 100.00 Very High Very High Very High
Enkephalin 86 100.00 Very High Very High Very High
Somatostatin 64 100.00 Very High Very High Very High
Neuropeptide 52 100.00 Very High Very High Very High
Endogenous opioid 19 100.00 Very High Very High Very High
Dynorphin 14 100.00 Very High Very High Very High
Cholecystokinin 7 100.00 Very High Very High Very High
tetrodotoxin 11 99.96 Very High Very High Very High
antagonist 281 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 307 100.00 Very High Very High Very High
Pancreatitis 28 99.68 Very High Very High Very High
Urological Neuroanatomy 83 99.60 Very High Very High Very High
Pox Virus Infection 5 99.56 Very High Very High Very High
Starvation 84 99.48 Very High Very High Very High
Bacterial Infection 2 99.34 Very High Very High Very High
Disease 344 99.26 Very High Very High Very High
Hypotension 8 99.02 Very High Very High Very High
Pain 36 99.00 Very High Very High Very High
Shock 16 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an ongoing trial in rat neurons we have observed how TRH produces slowly developing but persisting motoneuron depolarization characterized by steady action potential discharges.
Gene_expression (produces) of TRH in neurons associated with action potential
1) Confidence 0.78 Published 1990 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 2127685 Disease Relevance 0.15 Pain Relevance 0.30
The present data provide evidence that bombesin and TRH produce opposite actions on thermoregulation of the mrf in the rat.
Gene_expression (produce) of TRH
2) Confidence 0.78 Published 1986 Journal Endocrinology Section Abstract Doc Link 3093200 Disease Relevance 0 Pain Relevance 0.16
These observations raise the possibility that treatments targeting TRH expression, the receptor for this biologically active peptide, or related signaling molecules, could be useful in treating or preventing L-DOPA-induced dyskinesias in human PD.


Gene_expression (expression) of TRH associated with disease and dyskinesias
3) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.50 Pain Relevance 0.23
Our findings suggest that up-regulation of striatal expression of TRH in the striatum and its output pathways is strongly correlated with the expression of L-DOPA induced dyskinesia and that this up-regulation could be an essential feature of the dyskinetic state in parkinsonism.
Gene_expression (expression) of TRH in striatum associated with parkinson's disease and dyskinesias
4) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.46 Pain Relevance 0.25
In addition, there appeared to be differential up-regulation of TRH expression in caudal parts of the striosomal system, judging from the immunohistochemistry.
Gene_expression (expression) of TRH in caudal parts
5) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.12 Pain Relevance 0.14
The biosynthesis of TRH (pyroGlu-His-ProNH2) begins with mRNA-directed ribosomal translation of a larger inactive precursor called proTRH (Figure 1D).
Gene_expression (biosynthesis) of TRH
6) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.30 Pain Relevance 0.12
By immunohistochemistry, we observed a pronounced and patterned increase in proTRH immunostaining in the striatum, with the strongest proTRH expression concentrated in the lateral and ventrolateral striatum including the sensorimotor striatum.
Gene_expression (expression) of proTRH in striatum
7) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.43 Pain Relevance 0.26
Thyrotropin-releasing hormone (TRH) produced a contraction in the isolated segment of duodenum and taenia coli of the guinea-pig (pA2, 8.0 and 8.9).
Gene_expression (produced) of TRH in duodenum
8) Confidence 0.78 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6104604 Disease Relevance 0 Pain Relevance 0.10
Thyrotropin-releasing hormone (TRH) produced a contraction in the isolated segment of duodenum and taenia coli of the guinea-pig (pA2, 8.0 and 8.9).
Gene_expression (produced) of Thyrotropin-releasing hormone in duodenum
9) Confidence 0.78 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6104604 Disease Relevance 0 Pain Relevance 0.10
Biochemical mechanisms by which analogs of thyrotropin-releasing hormone (TRH) produce their potent neuropharmacological actions on the brain remain ill-defined.
Gene_expression (produce) of TRH in brain
10) Confidence 0.78 Published 1995 Journal Endocr. Res. Section Abstract Doc Link 8582330 Disease Relevance 0 Pain Relevance 0.06
When given during the hypotensive response to alpha-methyldopa, both naloxone and TRH produce a pressor response.
Gene_expression (produce) of TRH associated with hypotension and narcan
11) Confidence 0.78 Published 1984 Journal Endocrinology Section Abstract Doc Link 6094160 Disease Relevance 0.36 Pain Relevance 0.40
Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats.
Gene_expression (Expression) of TRH in central nervous system associated with central nervous system
12) Confidence 0.77 Published 2000 Journal J. Comp. Neurol. Section Title Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.24
Expression of thyrotropin-releasing hormone receptor 2 (TRH-R2) in the central nervous system of rats.
Gene_expression (Expression) of thyrotropin-releasing hormone in central nervous system associated with central nervous system
13) Confidence 0.77 Published 2000 Journal J. Comp. Neurol. Section Title Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.24
In accordance with the well-known endocrine function of TRH, TRH-R1 is found predominantly expressed in hypothalamic regions.
Gene_expression (expressed) of TRH
14) Confidence 0.77 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.29
Brain stem TRH is synthesized in caudal raphe nuclei innervating brainstem and spinal vagal and sympathetic motor neurons.
Gene_expression (synthesized) of TRH in brainstem associated with medulla and raphe
15) Confidence 0.77 Published 2006 Journal Endocrinology Section Abstract Doc Link 16959836 Disease Relevance 0.10 Pain Relevance 0.19
Thyrotropin-releasing hormone (TRH) is abundantly present in the pancreas.
Gene_expression (present) of Thyrotropin-releasing hormone in pancreas
16) Confidence 0.76 Published 1992 Journal Hepatogastroenterology Section Abstract Doc Link 1459520 Disease Relevance 0.46 Pain Relevance 0.38
Thyrotropin-releasing hormone (TRH) is abundantly present in the pancreas.
Gene_expression (present) of TRH in pancreas
17) Confidence 0.76 Published 1992 Journal Hepatogastroenterology Section Abstract Doc Link 1459520 Disease Relevance 0.46 Pain Relevance 0.38
The possibility that TRH directly modulated histamine release at nerve terminals in these sites cannot be excluded; however, it is likely that TRH activates histaminergic neurons within the TMN, and thereafter induces histamine release from the nerve terminals at projection sites because TRH receptors are expressed on the cell bodies of histaminergic neurons within the TMN.
Gene_expression (expressed) of TRH in neurons
18) Confidence 0.75 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.06 Pain Relevance 0.07
In addition, TRH-R1 expressed in other regions, such as the brain stem and spinal cord support a functional link between TRH and vegetative and autonomic functions.
Gene_expression (expressed) of TRH in spinal cord associated with spinal cord
19) Confidence 0.75 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.13 Pain Relevance 0.18
Because leptin increases TRH expression in the PVN (Flier and Maratos-Flier 1998; Mantzoros 1999; Nillni et al. 2000), and in light of our finding a functional and neuroanatomical link between TRH and neuronal histamine, it is likely that leptin may activate histaminergic neurons indirectly via neurons that release TRH.



Gene_expression (expression) of TRH in neurons
20) Confidence 0.75 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.07 Pain Relevance 0

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