INT232317

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.21
Pain Relevance 2.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C12orf39) nucleolus (C12orf39) nucleus (C12orf39)
Anatomy Link Frequency
brain 1
external 1
C12orf39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 3 98.04 Very High Very High Very High
alcohol 3 96.20 Very High Very High Very High
Pain 264 94.88 High High
Serotonin 3 94.72 High High
referred pain 12 66.84 Quite High
Locus ceruleus 3 56.48 Quite High
Neuropeptide 93 9.56 Low Low
Central grey 21 8.08 Low Low
Neurotransmitter 9 5.00 Very Low Very Low Very Low
backache 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 117 94.88 High High
Neck Pain 141 89.88 High High
Hypersensitivity 21 89.32 High High
Lung Cancer 3 71.00 Quite High
Referred Pain 12 66.84 Quite High
Decapitation 3 58.52 Quite High
Urological Neuroanatomy 21 8.08 Low Low
Low Back Pain 15 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An initial mapping study of preproNPQ mRNA demonstrated that its expression in the brain is restricted to the mesopontine tegmentum.
Gene_expression (expression) of NPQ in brain
1) Confidence 0.75 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2603333 Disease Relevance 0.07 Pain Relevance 0.03
Radioactive probes for preproNPQ, tyrosine hydroxylase (TH; synthetic enzyme for dopamine and norepinephrine), tryptophan hydroxylase 2 (TPH2; synthetic enzyme for serotonin), choline acetyltransferase (ChAT; synthetic enzyme for acetylcholine), and corticotropin-releasing factor (CRF) were prepared from E. coli containing pBluescript SK cloning vectors (Stratagene, San Diego, CA), which were grown at 37°C for 16 hours in a shaker.
Gene_expression (probes) of NPQ associated with dopamine and serotonin
2) Confidence 0.65 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2603333 Disease Relevance 0.15 Pain Relevance 0.14
The blot was prehybridized and probed with human NPQ cDNA prepared using the above preproNPQ human primers and the human DNA clone in pOTB7 vector from ATCC (Cat # 6710068, Manassas, VA).
Gene_expression (prepared) of NPQ cDNA
3) Confidence 0.29 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2603333 Disease Relevance 0 Pain Relevance 0
According to these results, NPQ is the second best and COM is the worst.
Gene_expression (best) of NPQ
4) Confidence 0.09 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2375887 Disease Relevance 0.68 Pain Relevance 0.68
In fact, this study was performed in routine conditions, no patient left the NDI and NPQ questionnaires unanswered, and only 4 out of 221 (1.8%) left the COM unanswered (Table 2).
Gene_expression (questionnaires) of NPQ
5) Confidence 0.09 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2375887 Disease Relevance 0.84 Pain Relevance 0.84
Results of NDI, NPQ and COM were consistent with the external criterion for disability, so that values for those questionnaires were higher as patient's self-perception of disability increased (Table 5).
Gene_expression (Results) of NPQ in external
6) Confidence 0.08 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2375887 Disease Relevance 0.46 Pain Relevance 0.46

General Comments

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