INT232361

Context Info Confidence 0.49 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.11 Pain Relevance 0

mitochondrion (Agxt) peroxisome (Agxt)

Agxt (Rattus norvegicus)

Pain Link Frequency Relevance Heat cva 6 5.00 Neuronal excitability 3 5.00 Action potential 3 5.00 eye pain 2 5.00 fibrosis 2 5.00 Inflammation 2 5.00 intrathecal 2 5.00 vincristine 2 5.00 imagery 2 5.00 hyperexcitability 1 5.00

Disease Link Frequency Relevance Heat Glioma 74 57.04 Cancer 62 47.88 Anaplastic Astrocytoma 4 32.48 Primitive Neuroectodermal Tumors 2 31.76 Infection 10 17.84 Glioblastoma 28 5.00 Toxicity 20 5.00 Brain Tumor 18 5.00 Recurrence 14 5.00 Pressure And Volume Under Development 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).

Positive_regulation (alkyltransferase) of Gene_expression (alkyltransferase) of AGT

1) Confidence 0.49 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0

The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).

Positive_regulation (conducted) of Gene_expression (alkyltransferase) of AGT

2) Confidence 0.49 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0

In accordance with these results, our SPT studies revealed that both treatments significantly reduced the synaptic dwell time of Eag1 (0.52±0.04 s, n?

Positive_regulation (accordance) of Gene_expression (studies) of SPT

3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810327 Disease Relevance 0 Pain Relevance 0

General Comments

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