INT232362

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 16
Disease Relevance 8.08
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mgmt) nucleus (Mgmt) DNA binding (Mgmt)
Mgmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 24 93.80 High High
Central nervous system 18 93.12 High High
anticonvulsant 47 56.88 Quite High
vincristine 14 53.92 Quite High
corticosteroid 15 50.36 Quite High
imagery 51 34.48 Quite Low
cva 35 5.00 Very Low Very Low Very Low
palliative 14 5.00 Very Low Very Low Very Low
Antiemetics 12 5.00 Very Low Very Low Very Low
dexamethasone 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 147 99.88 Very High Very High Very High
Death 52 99.64 Very High Very High Very High
Apoptosis 14 99.20 Very High Very High Very High
Cancer 533 98.96 Very High Very High Very High
Disease Progression 56 98.40 Very High Very High Very High
Brain Tumor 123 95.76 Very High Very High Very High
Metastasis 92 87.08 High High
Lung Cancer 22 84.80 Quite High
Glioma 445 84.04 Quite High
Pneumocystis Pneumonia 47 81.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These investigators hypothesized that tumors with hypermethylation (inactivation) of the methylguanine methyltransferase (MGMT) gene would have a better prognosis that those patients with only unmethylated, therefore active expression of the MGMT gene.
Gene_expression (expression) of MGMT gene associated with cancer
1) Confidence 0.76 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387286 Disease Relevance 0.39 Pain Relevance 0
Studies are also underway to develop molecular markers, such as expression of MGMT that may help select the patients most likely to benefit from this treatment.



Gene_expression (expression) of MGMT
2) Confidence 0.76 Published 2007 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2387286 Disease Relevance 0.65 Pain Relevance 0.08
Prior studies had identified MGMT expression as a potential mechanism of resistance to alkylating agent chemotherapy including temozolomide.
Gene_expression (expression) of MGMT
3) Confidence 0.76 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387286 Disease Relevance 0.38 Pain Relevance 0
These investigators hypothesized that tumors with hypermethylation (inactivation) of the methylguanine methyltransferase (MGMT) gene would have a better prognosis that those patients with only unmethylated, therefore active expression of the MGMT gene.
Gene_expression (expression) of MGMT associated with cancer
4) Confidence 0.66 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387286 Disease Relevance 0.40 Pain Relevance 0
Methylguanine methyltransferase (MGMT) analysis
Gene_expression (Methylguanine methyltransferase) of MGMT
5) Confidence 0.66 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387286 Disease Relevance 0.42 Pain Relevance 0
O6-methylguanine-DNA methyltransferase (MGMT) is a key DNA repair enzyme responsible for tumor resistance to alkylating agents [14, 15].
Gene_expression (methyltransferase) of MGMT associated with cancer
6) Confidence 0.43 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2826096 Disease Relevance 0.97 Pain Relevance 0.14
O6-methylguanine-DNA methyltransferase (MGMT) is a key DNA repair enzyme responsible for tumor resistance to alkylating agents [14, 15].
Gene_expression (methyltransferase) of O6-methylguanine-DNA associated with cancer
7) Confidence 0.43 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2826096 Disease Relevance 0.98 Pain Relevance 0.14
The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).
Gene_expression (alkyltransferase) of MGMT
8) Confidence 0.40 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0
The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).
Gene_expression (alkyltransferase) of O6-alkylguanine-DNA
9) Confidence 0.40 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0
MGMT effectively reverses the cytotoxic action of TMZ and thus high MGMT expression levels are associated with TMZ resistance.
Gene_expression (expression) of MGMT
10) Confidence 0.13 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.47 Pain Relevance 0.03
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Gene_expression (expression) of MGMT gene associated with cancer
11) Confidence 0.13 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.52 Pain Relevance 0
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Gene_expression (expression) of MGMT gene associated with cancer
12) Confidence 0.13 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.48 Pain Relevance 0
Conversely, a deficient MMR system coupled with high MGMT expression levels may mediate TMZ resistance.44,45

TMZ toxicity profile

Gene_expression (expression) of MGMT associated with toxicity
13) Confidence 0.13 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.84 Pain Relevance 0
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Gene_expression (expression) of MGMT associated with cancer
14) Confidence 0.13 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.52 Pain Relevance 0
In the presence of the DNA repair enzyme O-6-methlguanine-DNA methyltransferase (MGMT, a DNA repair enzyme that removes methyl adducts at the O-6 position of guanine added by TMZ),43 the methylation of guanine can be repaired thereby allowing the cells to escape TMZ-induced cell death.
Gene_expression (presence) of MGMT associated with death
15) Confidence 0.11 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.47 Pain Relevance 0
MGMT effectively reverses the cytotoxic action of TMZ and thus high MGMT expression levels are associated with TMZ resistance.
Gene_expression (expression) of MGMT
16) Confidence 0.10 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.48 Pain Relevance 0.03

General Comments

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