INT232363

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 13
Disease Relevance 6.01
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Mgmt) nucleus (Mgmt) DNA binding (Mgmt)
Mgmt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bioavailability 11 93.80 High High
Central nervous system 13 93.12 High High
vincristine 11 48.28 Quite Low
imagery 29 34.48 Quite Low
cva 27 5.00 Very Low Very Low Very Low
palliative 12 5.00 Very Low Very Low Very Low
anticonvulsant 11 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
Antiemetics 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 141 99.88 Very High Very High Very High
Cancer 437 98.96 Very High Very High Very High
Disease Progression 36 98.40 Very High Very High Very High
Brain Tumor 94 95.76 Very High Very High Very High
Death 56 93.00 High High
Metastasis 100 87.08 High High
Lung Cancer 26 84.80 Quite High
Pneumocystis Pneumonia 37 81.80 Quite High
Apoptosis 12 81.08 Quite High
Vomiting 67 79.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylguanine methyltransferase (MGMT) analysis
Positive_regulation (Methylguanine methyltransferase) of Gene_expression (Methylguanine methyltransferase) of MGMT
1) Confidence 0.49 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387286 Disease Relevance 0.42 Pain Relevance 0
O6-methylguanine-DNA methyltransferase (MGMT) is a key DNA repair enzyme responsible for tumor resistance to alkylating agents [14, 15].
Positive_regulation (methyltransferase) of Gene_expression (methyltransferase) of MGMT associated with cancer
2) Confidence 0.32 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2826096 Disease Relevance 0.97 Pain Relevance 0.14
O6-methylguanine-DNA methyltransferase (MGMT) is a key DNA repair enzyme responsible for tumor resistance to alkylating agents [14, 15].
Positive_regulation (methyltransferase) of Gene_expression (methyltransferase) of O6-methylguanine-DNA associated with cancer
3) Confidence 0.32 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2826096 Disease Relevance 0.98 Pain Relevance 0.14
The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).
Positive_regulation (conducted) of Gene_expression (alkyltransferase) of MGMT
4) Confidence 0.30 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0
The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).
Positive_regulation (conducted) of Gene_expression (alkyltransferase) of O6-alkylguanine-DNA
5) Confidence 0.30 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0
The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).
Positive_regulation (alkyltransferase) of Gene_expression (alkyltransferase) of O6-alkylguanine-DNA
6) Confidence 0.30 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0
The repair of the chloroethyl adducts is conducted by O6-alkylguanine-DNA alkyltransferase (AGT or MGMT).
Positive_regulation (alkyltransferase) of Gene_expression (alkyltransferase) of MGMT
7) Confidence 0.30 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376068 Disease Relevance 0.06 Pain Relevance 0
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Positive_regulation (high) of Gene_expression (expression) of MGMT gene associated with cancer
8) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.52 Pain Relevance 0
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Positive_regulation (unmethylated) of Gene_expression (expression) of MGMT gene associated with cancer
9) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.52 Pain Relevance 0
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Positive_regulation (unmethylated) of Gene_expression (expression) of MGMT associated with cancer
10) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.52 Pain Relevance 0
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Positive_regulation (high) of Gene_expression (expression) of MGMT associated with cancer
11) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.52 Pain Relevance 0
Patients with silenced MGMT gene expression due to hypermethylation of MGMT promoters were shown to respond more favorably to concurrent TMZ/RT compared with those who had unmethylated MGMT promoters and high MGMT gene expression levels.99 In this study, tumor samples obtained from nGBM patients enrolled in the EORTC/NCIC phase III study were analyzed for MGMT promoter methylation status by methylation-specific polymerase chain reaction techniques99 (Table 8).


Positive_regulation (silenced) of Gene_expression (expression) of MGMT gene associated with cancer
12) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.48 Pain Relevance 0
Conversely, a deficient MMR system coupled with high MGMT expression levels may mediate TMZ resistance.44,45

TMZ toxicity profile

Positive_regulation (high) of Gene_expression (expression) of MGMT associated with toxicity
13) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899776 Disease Relevance 0.84 Pain Relevance 0

General Comments

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