INT232384

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (BCR, C6orf25) cytosol (BCR) signal transduction (BCR)
Golgi apparatus (C6orf25) endoplasmic reticulum (C6orf25) kinase activity (BCR)
Anatomy Link Frequency
B-cells 1
BCR (Homo sapiens)
C6orf25 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 2 49.04 Quite Low
Antihistamine 3 47.60 Quite Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
corticosteroid 7 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 96.84 Very High Very High Very High
Lymphatic System Cancer 16 83.76 Quite High
Systemic Lupus Erythematosus 23 77.44 Quite High
Solid Tumor 1 73.56 Quite High
Disease 11 73.00 Quite High
Cancer 1 71.36 Quite High
Epstein-barr Virus 1 68.28 Quite High
Hypersensitivity 2 53.04 Quite High
Autoimmune Disease 22 52.20 Quite High
Adhesions 2 9.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Its known mechanisms of action differ from the anti-CD20 monoclonal antibody which depletes very efficiently CD20+ B-cells, rituximab, by CD22 phosphorylation (Carnahan et al 2003) and by affecting BCR (via immobilized immunoglobulin crosslinking), as well as inducing moderate, but significant, ADCC, without showing direct apoptotic or complement-mediated killing (Carnahan et al 2003).
BCR Binding (crosslinking) of immunoglobulin in B-cells associated with apoptosis
1) Confidence 0.00 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.91 Pain Relevance 0

General Comments

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