INT232391

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGLL1)
Anatomy Link Frequency
B cells 2
IGLL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 48 97.80 Very High Very High Very High
methotrexate 59 92.12 High High
corticosteroid 9 80.72 Quite High
Antihistamine 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 22 98.68 Very High Very High Very High
Influenza Virus Infection 33 97.84 Very High Very High Very High
Rheumatoid Arthritis 48 97.80 Very High Very High Very High
Infection 19 95.52 Very High Very High Very High
Purpura 1 60.60 Quite High
Systemic Lupus Erythematosus 23 57.92 Quite High
Syndrome 6 56.96 Quite High
Immunization 9 49.92 Quite Low
Disease 24 46.84 Quite Low
Lymphatic System Cancer 16 44.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of B cells producing Pneumo23-specific switched Ig was lower (but not significant) as compared with the influenza-specific B cells.
Negative_regulation (switched) of Ig in B cells associated with influenza virus infection
1) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911904 Disease Relevance 0.46 Pain Relevance 0
Depleting B-cells is a new and interesting method in the treatment of autoimmune diseases, although there are still too limited long-term safety data, and reduced Ig levels indeed were reported in a 7-year experience in RA (Edwards and Cambridge 2006).
Negative_regulation (reduced) of Ig in B-cells associated with autoimmune disease and rheumatoid arthritis
2) Confidence 0.02 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.84 Pain Relevance 0.23
Although reductions in Ig levels (predominantly IgM) were observed, mean Ig levels stayed within normal limits, and there did not appear to be any association between reduced Ig concentrations and infection.
Negative_regulation (reductions) of Ig associated with infection
3) Confidence 0.01 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2938895 Disease Relevance 0.59 Pain Relevance 0.31

General Comments

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