INT232397

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 4
Disease Relevance 1.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
neck 1
cleavage 1
head 1
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 64 98.76 Very High Very High Very High
Skin Cancer 6 98.38 Very High Very High Very High
Cancer 4 94.08 High High
Apoptosis 10 90.80 High High
Leukoencephalopathies 2 53.76 Quite High
Cadasil 2 52.08 Quite High
Myocardial Infarction 2 27.36 Quite Low
Sprains And Strains 2 21.44 Low Low
Congenital Anomalies 2 20.28 Low Low
Infarction 2 19.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this scenario, without periostin, Notch1 precursor can not be well folded under the stress condition, causing the insufficient S1-cleaved heterodimeric Notch1 that is probably easily degraded, resulting in reduction of the N1™ level.
Protein_catabolism (degraded) of Notch1 associated with stress
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.68 Pain Relevance 0
It was previously reported that Notch1 is first synthesized as a 300-kDa precursor protein and that following the glycosylation step, Notch1 is cleaved by a furin-like convertase (site 1 cleavage; S1 cleavage) to form a heterodimer receptor composed of a 230-kDa extracellular domain (N1EC) and a 120-kDa transmembrane domain (N1™); and then the mature heterodimeric Notch1 is trafficked to the cell surface [17], [18].
Protein_catabolism (cleaved) of Notch1 in cleavage
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.13 Pain Relevance 0
Review of cetuximab in the treatment of squamous cell carcinoma of the head and neck

Cetuximab is a monoclonal antibody able to inhibit and to degrade the transmembrane receptor Her-1, also known as epidermal growth factor receptor (EGFR).

Protein_catabolism (degrade) of transmembrane receptor Her-1 in neck associated with skin cancer
3) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Title Doc Link PMC2376084 Disease Relevance 0.38 Pain Relevance 0
Review of cetuximab in the treatment of squamous cell carcinoma of the head and neck

Cetuximab is a monoclonal antibody able to inhibit and to degrade the transmembrane receptor Her-1, also known as epidermal growth factor receptor (EGFR).

Protein_catabolism (degrade) of transmembrane receptor Her-1 in head associated with skin cancer
4) Confidence 0.00 Published 2007 Journal Therapeutics and Clinical Risk Management Section Title Doc Link PMC2376084 Disease Relevance 0.38 Pain Relevance 0

General Comments

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