INT23240

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Context Info
Confidence 0.13
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 16.77
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
plasma 3
liver 1
hepatocyte 1
tendon 1
biliary tract 1
got1 (Xenopus laevis)
Pain Term Frequency Confidence Heat
Pain 8 99.92 Very High Very High Very High
abdominal pain 15 99.90 Very High Very High Very High
Chronic pancreatitis 2 99.40 Very High Very High Very High
Bile 66 98.42 Very High Very High Very High
Paracetamol 18 98.28 Very High Very High Very High
Inflammation 47 98.12 Very High Very High Very High
cytokine 32 93.88 High High
lidocaine 3 92.64 High High
depression 9 91.76 High High
fibrosis 5 89.72 High High
Disease Term Frequency Confidence Heat
Necrosis 14 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 7 100.00 Very High Very High Very High
Acute Renal Failure 2 99.96 Very High Very High Very High
Pain 4 99.92 Very High Very High Very High
Abdominal Pain 15 99.90 Very High Very High Very High
Fever 27 99.54 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 4 99.52 Very High Very High Very High
Pancreatitis 5 99.40 Very High Very High Very High
Leukocytosis 3 99.26 Very High Very High Very High
Injury 144 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transient increases (grades 1-3) in the levels of creatinine kinase, aspartate aminotransferase, and alanine transaminase attributed to crotoxin myotoxicity were observed but returned to normal by the last week of treatment.
Positive_regulation (increases) of aspartate aminotransferase
1) Confidence 0.13 Published 2002 Journal Clin. Cancer Res. Section Abstract Doc Link 11948110 Disease Relevance 1.49 Pain Relevance 0
In the presence of an inhibitor of NO synthesis, NG-monomethyl-L-arginine (L-NMMA), hepatocyte release of aspartate aminotransferase was increased twofold in the presence of 4.0 and 8.0 mM AM (P < 0.01).
Positive_regulation (increased) of aspartate aminotransferase in hepatocyte associated with paracetamol
2) Confidence 0.09 Published 1994 Journal J. Surg. Res. Section Abstract Doc Link 8015316 Disease Relevance 0.35 Pain Relevance 0.82
Aspartate aminotransferase, alanine transaminase, and creatine kinase levels were significantly elevated after the procedure (190 +/- 47.1 U/liter, 50 +/- 7.7 U/liter, and 11,219 +/- 2556.7 U/liter, respectively) (p < 0.01).
Positive_regulation (elevated) of Aspartate aminotransferase
3) Confidence 0.09 Published 2004 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 15318060 Disease Relevance 0.58 Pain Relevance 0
Elevated aspartate aminotransferase, alanine transaminase, and creatine kinase levels are associated with skeletal muscle injury, adipocyte lysis, and/or hepatic damage.
Positive_regulation (Elevated) of aspartate aminotransferase in adipocyte associated with injury
4) Confidence 0.09 Published 2004 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 15318060 Disease Relevance 0.75 Pain Relevance 0
Arguments for a pre-existing primary myopathy are the generally reduced tendon reflexes, the elevated CK, GOT, and GPT, the chronic pancreatitis, the psychotic episode, and the renal insufficiency, although it cannot be excluded that these abnormalities were due to previous anti-viral therapy or other causes.
Positive_regulation (elevated) of GOT in tendon associated with congenital anomalies, psychosis, renal insufficiency, muscle disease and chronic pancreatitis
5) Confidence 0.08 Published 2010 Journal Virol J Section Body Doc Link PMC2998482 Disease Relevance 0.98 Pain Relevance 0.10
In the porcine model for large-volume liposuction, plasma aspartate aminotransferase and alanine transaminase levels were elevated following liposuction.
Positive_regulation (elevated) of aspartate aminotransferase in plasma
6) Confidence 0.07 Published 2004 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 15318060 Disease Relevance 0.18 Pain Relevance 0.09
All had markedly elevated serum transaminase values (aspartate aminotransferase greater than 4000 U/L) and prolonged prothrombin times.
Positive_regulation (elevated) of aspartate aminotransferase
7) Confidence 0.07 Published 1990 Journal South. Med. J. Section Abstract Doc Link 2402650 Disease Relevance 0.17 Pain Relevance 0.27
After evaluating the changes of several biochemical parameters in serum, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were elevated by APAP (500 mg/kg) intraperitoneal administration (8 and 24 h) and reduced by treatment with magnolol (0.5 h after APAP administration; 0.01, 0.1, and 1 mug/kg).
Positive_regulation (elevated) of aspartate aminotransferase
8) Confidence 0.04 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 19280152 Disease Relevance 0.68 Pain Relevance 0.15
Patients who presented within 24 hours of ingestion and in whom increased aspartate aminotransferase (AST) levels developed during hospitalization were included in the data analysis.
Positive_regulation (increased) of aspartate aminotransferase
9) Confidence 0.04 Published 1995 Journal Ann Emerg Med Section Body Doc Link 7793720 Disease Relevance 0.09 Pain Relevance 0
Increases of aspartate aminotransferase and alanine aminotransferase occurred as delayed events.
Positive_regulation (Increases) of aspartate aminotransferase
10) Confidence 0.03 Published 2000 Journal Bone Marrow Transplant. Section Abstract Doc Link 11100272 Disease Relevance 0.10 Pain Relevance 0.10
Transaminases (aspartate aminotransferase and alanine aminotransferase) increased during mechanical ventilation in the supine position, while they were both unchanged in the prone position. ?
Positive_regulation (increased) of aspartate aminotransferase
11) Confidence 0.02 Published 2006 Journal Crit Care Section Body Doc Link PMC1550810 Disease Relevance 0.41 Pain Relevance 0.09
Aspartate-aminotransferase (AST) (p = 0.004), alanine-aminotransferase (ALT) (p = 0.0001), ammonia (p = 0.0001) and thiostatin (p = 0.0001) serum levels are higher in PCS-rats compared to control rats.
Positive_regulation (higher) of Aspartate-aminotransferase
12) Confidence 0.02 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2262055 Disease Relevance 0.36 Pain Relevance 0.03
Patients with fever or abdominal pain and increased levels of biliary enzymes, such as aspartate aminotransferase and alanine aminotransferase, and an elevated inflammatory reaction after treatment or surgery of the biliary tract, are often diagnosed as having retrograde cholangitis.
Positive_regulation (increased) of aspartate aminotransferase in biliary tract associated with cholangitis, abdominal pain, inflammation and fever
13) Confidence 0.01 Published 2007 Journal J Hepatobiliary Pancreat Surg Section Body Doc Link PMC2784504 Disease Relevance 1.35 Pain Relevance 0.22
An incidence as high as 50% has been described when there is transient elevation of the aspartate aminotransferase, alanine aminotransferase, and particularly the alkaline phosphatase.
Positive_regulation (elevation) of aspartate aminotransferase
14) Confidence 0.01 Published 2007 Journal J Burns Wounds Section Body Doc Link PMC1892842 Disease Relevance 1.49 Pain Relevance 0
A recent study of 504 patients, in which patients with baseline abnormal liver enzymes were excluded, showed no clinically significant alanine aminotransferase (ALT) and aspartate aminotransferase (AST) elevation in plasma levels when tested 6 weeks into the treatment (250 mg/day) (Pollak et al 2004).
Neg (no) Positive_regulation (elevation) of aspartate aminotransferase in plasma
15) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661633 Disease Relevance 0.78 Pain Relevance 0.05
Other significant findings included marked leukocytosis to 46.1 K/cmm, acute renal failure, elevation of troponin-I and marked transaminase elevations (aspartate aminotransferase (AST) 1711, alanine aminotransferase (ALT) 806) with normal international normalized ratio and alkaline phosphatase.
Positive_regulation (elevation) of aspartate aminotransferase associated with acute renal failure and leukocytosis
16) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2546413 Disease Relevance 1.03 Pain Relevance 0.12
Other significant findings included marked leukocytosis to 46.1 K/cmm, acute renal failure, elevation of troponin-I and marked transaminase elevations (aspartate aminotransferase (AST) 1711, alanine aminotransferase (ALT) 806) with normal international normalized ratio and alkaline phosphatase.
Positive_regulation (elevations) of aspartate aminotransferase associated with acute renal failure and leukocytosis
17) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2546413 Disease Relevance 1.01 Pain Relevance 0.12
With the exception of median ALT and aspartate aminotransferase (AST) serum levels, which were elevated as expected in patients suffering from hepatitis C, median serum levels of all other laboratory parameters were within the normal range at baseline.
Positive_regulation (elevated) of aspartate aminotransferase associated with hepatitis
18) Confidence 0.01 Published 2007 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2156112 Disease Relevance 0.62 Pain Relevance 0.13
The activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in rat plasma rise remarkably with hepatocyte necrosis and lipid accumulation when CCl4 is administered to rats.
Positive_regulation (accumulation) of aspartate aminotransferase in plasma associated with necrosis
19) Confidence 0.01 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2933434 Disease Relevance 0.46 Pain Relevance 0.04
Aqueous garlic extract (200 gm/l drinking water) for 10 days exhibited significantly higher levels of aspartate aminotransferase (AST) due to liver injury.
Positive_regulation (levels) of aspartate aminotransferase in liver associated with injury
20) Confidence 0.01 Published 2002 Journal Nutr J Section Body Doc Link PMC139960 Disease Relevance 0.81 Pain Relevance 0.05

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