INT232406

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.29
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 1
DFP (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 12 56.40 Quite High
Inflammation 3 54.32 Quite High
abdominal pain 3 27.36 Quite Low
imagery 6 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Iron Overload 54 99.96 Very High Very High Very High
Heart Disease 12 94.08 High High
Thalassemia 63 78.84 Quite High
Agranulocytosis 24 74.64 Quite High
Recurrence 3 71.96 Quite High
Viral Infection 3 69.96 Quite High
Neutropenia 12 65.80 Quite High
Lysosome Storage Disease 3 65.12 Quite High
Cirrhosis 15 57.04 Quite High
Cancer 3 56.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When using serum ferritin concentrations as a measure of iron overload, response to DFP therapy can be monitored and doses can be tailored to the needs of the patient to maintain concentrations below those associated with iron-induced heart disease.


Positive_regulation (response) of DFP in heart associated with heart disease and iron overload
1) Confidence 0.28 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.77 Pain Relevance 0.06
Ventricular ejection fraction also increased significantly more in the DFP group (3.1% vs 0.3%; p = 0.0034).
Positive_regulation (increased) of DFP
2) Confidence 0.28 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0 Pain Relevance 0
Alternate therapy is very common in clinical practice probably because by introducing oral DFP and reducing the weekly number of DFO infusions, it may be a practical approach to improve compliance with iron chelation for patients poorly compliant with DFO monotherapy.
Positive_regulation (introducing) of DFP
3) Confidence 0.26 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.53 Pain Relevance 0

General Comments

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