INT232406

Context Info Confidence 0.28 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 1.29 Pain Relevance 0.06

Anatomy Link Frequency heart 1 DFP (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 12 56.40 Inflammation 3 54.32 abdominal pain 3 27.36 imagery 6 5.00 Bile 3 5.00 tolerance 3 5.00 Pain 3 5.00

Disease Link Frequency Relevance Heat Iron Overload 54 99.96 Heart Disease 12 94.08 Thalassemia 63 78.84 Agranulocytosis 24 74.64 Recurrence 3 71.96 Viral Infection 3 69.96 Neutropenia 12 65.80 Lysosome Storage Disease 3 65.12 Cirrhosis 15 57.04 Cancer 3 56.20

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When using serum ferritin concentrations as a measure of iron overload, response to DFP therapy can be monitored and doses can be tailored to the needs of the patient to maintain concentrations below those associated with iron-induced heart disease.

Positive_regulation (response) of DFP in heart associated with heart disease and iron overload

1) Confidence 0.28 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.77 Pain Relevance 0.06

Ventricular ejection fraction also increased significantly more in the DFP group (3.1% vs 0.3%; p = 0.0034).

Positive_regulation (increased) of DFP

2) Confidence 0.28 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0 Pain Relevance 0

Alternate therapy is very common in clinical practice probably because by introducing oral DFP and reducing the weekly number of DFO infusions, it may be a practical approach to improve compliance with iron chelation for patients poorly compliant with DFO monotherapy.

Positive_regulation (introducing) of DFP

3) Confidence 0.26 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.53 Pain Relevance 0

General Comments

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