INT232417

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Mtx1 (Mus musculus)
Ifx (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 156 100.00 Very High Very High Very High
methotrexate 12 100.00 Very High Very High Very High
rheumatoid arthritis 112 87.76 High High
Pain scale 2 71.96 Quite High
Arthritis 4 44.00 Quite Low
spinal inflammation 2 43.16 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 58 98.04 Very High Very High Very High
Disease Progression 4 92.80 High High
Rheumatoid Arthritis 112 87.76 High High
Frailty 4 80.80 Quite High
Pain 4 71.72 Quite High
Arthritis 4 44.00 Quite Low
Low Back Pain 2 43.16 Quite Low
Infection 6 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 4 5.00 Very Low Very Low Very Low
Mycobacterial Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The largest double blind RCT, the ASPIRE trial (St Clair et al 2004), included 1049 patients, and compared the effect of methotrexate-IFX (MTX-IFX) with MTX-placebo on clinical, radiological, and functional scores at 1 year.
MTX Binding (effect) of methotrexate-IFX associated with infliximab and methotrexate
1) Confidence 0.04 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376089 Disease Relevance 0.41 Pain Relevance 0.50
Overall, the results of the different RCTs comparing MTX-IFX with MTX alone indicate that improvements on measures of disease activity are relatively modest.


MTX Binding (comparing) of IFX associated with infliximab and disease
2) Confidence 0.04 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376089 Disease Relevance 0.59 Pain Relevance 0.36

General Comments

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