INT232425

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) mitochondrion (ABAT)
extracellular region (PRL)
ABAT (Homo sapiens)
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 13 100.00 Very High Very High Very High
Neurotransmitter 6 100.00 Very High Very High Very High
agonist 23 95.66 Very High Very High Very High
antagonist 19 81.96 Quite High
Dopamine 63 73.88 Quite High
withdrawal 1 50.88 Quite High
Neurobehavioral 1 49.16 Quite Low
methadone 2 24.72 Low Low
cocaine 1 19.16 Low Low
Morphine 6 18.80 Low Low
Disease Link Frequency Relevance Heat
Galactorrhea 124 92.48 High High
Syndrome 1 49.52 Quite Low
Ulcers 2 36.48 Quite Low
Reprotox - General 1 28 5.00 Very Low Very Low Very Low
Schizophrenia 20 5.00 Very Low Very Low Very Low
Psychosis 17 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Reprotox - General 2 7 5.00 Very Low Very Low Very Low
Gynecomastia 7 5.00 Very Low Very Low Very Low
Hypertension 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that systemic administration of specific histamine-H2 agonist (impromidine) is not able to avoid the cimetidine-induced prolactin release, while pre-treatment with benzodiazepines or GABA respectively suppressed or reduced prolactin response, suggested that cimetidine does not induce prolactin hypersecretion through an action on histamine H2 receptors, but through the interaction with other neurotransmitters, such as the pituitaric GABA-ergic system (Sibilia et al 1985) (Figure 1).


GABA Binding (interaction) of Neg (not) Positive_regulation (induce) of prolactin associated with neurotransmitter, gaba and agonist
1) Confidence 0.09 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.15 Pain Relevance 0.33

General Comments

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