INT232426

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
plasma membrane (HRH2) signal transducer activity (HRH2)
HRH2 (Homo sapiens)
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
methadone 2 91.88 High High
cocaine 1 86.32 High High
Morphine 6 85.96 High High
Neurobehavioral 1 83.68 Quite High
withdrawal 1 79.84 Quite High
Dopamine 63 65.92 Quite High
narcan 1 58.56 Quite High
opiate 4 57.76 Quite High
Opioid 2 48.88 Quite Low
Disease Link Frequency Relevance Heat
Ulcers 2 100.00 Very High Very High Very High
Galactorrhea 124 98.60 Very High Very High Very High
Syndrome 1 82.40 Quite High
Hypertension 6 11.56 Low Low
Reprotox - General 1 28 5.00 Very Low Very Low Very Low
Schizophrenia 20 5.00 Very Low Very Low Very Low
Psychosis 17 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Reprotox - General 2 7 5.00 Very Low Very Low Very Low
Gynecomastia 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although histamine H2-receptor competitive antagonists cimetidine and ranitidine, used in active ulcers, ulcer prophylaxis and gastric hypersecretory conditions, have stimulatory effect on prolactin secretion (Perret et al 1986; Knigge 1990), hyperprolactinemia has never been systematically reported, except for isolated case reports published shortly after the approval of the drugs (Petrillo et al 1977).
H2-receptor Regulation (effect) of Localization (secretion) of prolactin associated with galactorrhea, antagonist and ulcers
1) Confidence 0.15 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.38 Pain Relevance 0.94

General Comments

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