INT232445

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
lactotrophs 6
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 91.40 High High
Serotonin 96 87.28 High High
Dopamine 189 85.60 High High
Neuropeptide 6 84.68 Quite High
gABA 39 80.80 Quite High
GABAergic 3 71.76 Quite High
Raphe 3 65.24 Quite High
Somatostatin 6 32.88 Quite Low
Opioid 6 5.76 Low Low
agonist 69 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Galactorrhea 372 5.00 Very Low Very Low Very Low
Reprotox - General 1 84 5.00 Very Low Very Low Very Low
Schizophrenia 60 5.00 Very Low Very Low Very Low
Psychosis 51 5.00 Very Low Very Low Very Low
Depression 27 5.00 Very Low Very Low Very Low
Reprotox - General 2 21 5.00 Very Low Very Low Very Low
Gynecomastia 21 5.00 Very Low Very Low Very Low
Hypertension 18 5.00 Very Low Very Low Very Low
Vomiting 12 5.00 Very Low Very Low Very Low
Eating Disorder 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estrogens modulate prolactin secretion in response to reproductive events through different mechanisms: amplification of mitotic activity of the lactotrophs, enhancement of prolactin gene transcription and translation through ER?
Positive_regulation (enhancement) of Transcription (transcription) of prolactin in lactotrophs
1) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.41
Estrogens modulate prolactin secretion in response to reproductive events through different mechanisms: amplification of mitotic activity of the lactotrophs, enhancement of prolactin gene transcription and translation through ER?
Positive_regulation (through) of Transcription (transcription) of prolactin in lactotrophs
2) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.40
VIP (and a fragment of its precursor named peptide his-isoleucine) acts both via hypothalamic afferents and direct paracrine and autocrine mechanisms, through lactotroph cell receptors binding, enhancing adenylate cyclase activity and increasing prolactin gene transcription.
Positive_regulation (increasing) of Transcription (transcription) of prolactin in lactotroph
3) Confidence 0.50 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.51

General Comments

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