INT232449

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
lactotroph 2
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 63 96.28 Very High Very High Very High
gABA 13 91.28 High High
Somatostatin 2 90.80 High High
Serotonin 32 42.16 Quite Low
Raphe 1 25.52 Quite Low
agonist 23 5.00 Very Low Very Low Very Low
antagonist 19 5.00 Very Low Very Low Very Low
antidepressant 17 5.00 Very Low Very Low Very Low
sSRI 17 5.00 Very Low Very Low Very Low
dopamine receptor 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Galactorrhea 124 5.00 Very Low Very Low Very Low
Reprotox - General 1 28 5.00 Very Low Very Low Very Low
Schizophrenia 20 5.00 Very Low Very Low Very Low
Psychosis 17 5.00 Very Low Very Low Very Low
Depression 9 5.00 Very Low Very Low Very Low
Reprotox - General 2 7 5.00 Very Low Very Low Very Low
Gynecomastia 7 5.00 Very Low Very Low Very Low
Hypertension 6 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low
Eating Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dopamine-mediated inhibition of prolactin secretion occurs through the binding of D2 receptors on the membrane of lactotroph cells and involves several signal transduction systems, resulting in inhibition of prolactin gene transcription, reduction of prolactin synthesis and release.
Negative_regulation (inhibition) of Transcription (transcription) of prolactin in lactotroph associated with dopamine
1) Confidence 0.59 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.30

General Comments

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