INT23245

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Context Info
Confidence 0.69
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 14.81
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
T cell 8
blood 3
plasma 2
macrophages 2
follicle 2
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 192 100.00 Very High Very High Very High
metalloproteinase 142 100.00 Very High Very High Very High
Inflammatory mediators 24 100.00 Very High Very High Very High
Morphine 25 99.98 Very High Very High Very High
Clonidine 3 99.82 Very High Very High Very High
rheumatoid arthritis 1 98.80 Very High Very High Very High
Inflammation 251 98.52 Very High Very High Very High
Parenteral administration 2 98.44 Very High Very High Very High
cINOD 2 98.00 Very High Very High Very High
opioid receptor 3 93.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 314 100.00 Very High Very High Very High
Adhesions 6 99.96 Very High Very High Very High
Pulmonary Disease 281 99.84 Very High Very High Very High
Nicotine Addiction 351 99.76 Very High Very High Very High
Pancreatitis 3 99.72 Very High Very High Very High
Disease 33 98.96 Very High Very High Very High
Rheumatoid Arthritis 1 98.80 Very High Very High Very High
Cancer 23 98.72 Very High Very High Very High
Necrosis 24 98.48 Very High Very High Very High
Bordatella Infection 6 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pancreatitis there was an increased expression of FAP protein in the acinar tissue in relation to inflammatory changes.
Positive_regulation (increased) of Gene_expression (expression) of FAP protein associated with inflammation and pancreatitis
1) Confidence 0.69 Published 1990 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 2403740 Disease Relevance 1.10 Pain Relevance 0.21
We investigated the intracellular mechanism by which morphine controls CD4+ T cell differentiation and demonstrate that morphine treatment in vitro 1) increases anti CD3/CD28 Ab-induced CD4+ T cell IL-4 protein synthesis, IL-4 mRNA, and GATA-3 mRNA accumulation through a pertussis toxin-sensitive receptor; 2) results in a dose-dependent increase in anti-CD3/CD28 Ab-induced CD4+ T cell cytoplasmic cAMP concentration; and 3) increases the forskolin-stimulated cytoplasmic cAMP level through a pertussis toxin-sensitive receptor.
Positive_regulation (increases) of Gene_expression (synthesis) of cell in T cell associated with bordatella infection and morphine
2) Confidence 0.67 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16272288 Disease Relevance 0.43 Pain Relevance 0.56
Nine of these patients with normal basal serum FSH and 22 normal controls (five of whom had had a normal response to previous gonadotrophin stimulation) were prospectively subjected to: (i) transvaginal pulsed colour Doppler ultrasound evaluation of the vessels surrounding the dominant follicle for blood flow impedance analysis, (ii) the clonidine test to explore the ability of the pituitary to release growth hormone, and (iii) detection of anti-granulosa cell auto-antibodies in blood using an enzyme-linked immunosorbent assay (ELISA).
Positive_regulation (explore) of Gene_expression (detection) of cell in follicle associated with clonidine
3) Confidence 0.49 Published 1994 Journal Hum. Reprod. Section Abstract Doc Link 7929726 Disease Relevance 0 Pain Relevance 0.16
Many different drugs, including non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, rheumatoid arthritis disease-modifying agents and phosphodiesterase inhibitors, interfere with the expression and/or function of cell adhesion receptors and this effect accounts for, at least in part, their anti-inflammatory activity.
Positive_regulation (interfere) of Gene_expression (expression) of cell associated with inflammation, rheumatoid arthritis, cinod, disease and adhesions
4) Confidence 0.49 Published 2001 Journal Expert Opin Pharmacother Section Abstract Doc Link 11336564 Disease Relevance 1.05 Pain Relevance 0.53
Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway.
Positive_regulation (induces) of Gene_expression (expression) of cell in T cell associated with morphine
5) Confidence 0.49 Published 2005 Journal J. Immunol. Section Title Doc Link 16272288 Disease Relevance 0.39 Pain Relevance 0.50
We investigated the intracellular mechanism by which morphine controls CD4+ T cell differentiation and demonstrate that morphine treatment in vitro 1) increases anti CD3/CD28 Ab-induced CD4+ T cell IL-4 protein synthesis, IL-4 mRNA, and GATA-3 mRNA accumulation through a pertussis toxin-sensitive receptor; 2) results in a dose-dependent increase in anti-CD3/CD28 Ab-induced CD4+ T cell cytoplasmic cAMP concentration; and 3) increases the forskolin-stimulated cytoplasmic cAMP level through a pertussis toxin-sensitive receptor.
Positive_regulation (increases) of Gene_expression (synthesis) of cell in T cell associated with bordatella infection and morphine
6) Confidence 0.49 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16272288 Disease Relevance 0.43 Pain Relevance 0.56
METHODS: Human Jurkat T-lymphoma cells overexpressing the antiapoptotic protein B-cell lymphoma 2 as well as cells deficient of caspase 9, caspase 8, or Fas-associated protein with death domain were exposed to lidocaine and compared with parental cells.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of cell in B-cell
7) Confidence 0.49 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.10 Pain Relevance 0
METHODS: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of cell in T cell
8) Confidence 0.49 Published 2008 Journal Ophthalmic Res. Section Body Doc Link 18421237 Disease Relevance 0.19 Pain Relevance 0
This apparent broad distribution of CEase expression, however, has been questioned in a recent report of tissue levels of CEase mRNA in which only pancreatic and intestinal tissues were positive [18].


Positive_regulation (distribution) of Gene_expression (expression) of CEase
9) Confidence 0.46 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.29 Pain Relevance 0.09
Other studies, however, did not support a role for CEase in transport of unesterified cholesterol to enterocytes; uptake of cholesterol by Caco-2 cells has been reported to be independent of added CEase or of transfection with CEase cDNA [24,25].
Neg (independent) Positive_regulation (independent) of Gene_expression (transfection) of CEase in Caco-2
10) Confidence 0.46 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.20 Pain Relevance 0.03
Morphine administration was also found to inhibit IL-4 induced up-regulation of MHC II RT1.B beta cell surface expression on B lymphocytes.
Positive_regulation (up-regulation) of Gene_expression (expression) of cell in beta cell associated with morphine
11) Confidence 0.45 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14742686 Disease Relevance 0 Pain Relevance 0.65
The amount of BAL MMP-12+-macrophages was also significantly higher in COPD groups than in controls in percentages and absolute values.
Positive_regulation (higher) of Gene_expression (amount) of BAL in macrophages associated with pulmonary disease and metalloproteinase
12) Confidence 0.19 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.88 Pain Relevance 0.37
The recovery of BAL did not differ between both 'healthy' smokers and healthy never-smokers.
Positive_regulation (recovery) of Gene_expression (recovery) of BAL associated with nicotine addiction
13) Confidence 0.19 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 3.55 Pain Relevance 0.07
Commercially available ELISA assays were used to measure BAL and plasma levels of human interleukin 8 (IL-8), tumor necrosis factor alpha (TNF-?)
Positive_regulation (measure) of Gene_expression (levels) of BAL in plasma associated with necrosis and cancer
14) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2887148 Disease Relevance 0.26 Pain Relevance 0.14
The use of urea to quantify the amount of ELF recovered by BAL is based on the knowledge that urea is freely diffusible through most body compartments, including the lungs.
Positive_regulation (recovered) of Gene_expression (recovered) of BAL in lungs
15) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2887148 Disease Relevance 0.14 Pain Relevance 0.16
and IL-8 levels in bronchoalveolar lavage (BAL) fluid were stable in the low VT group but increased in the high VT group (P = 0.04 and P = 0.03).
Positive_regulation (increased) of Gene_expression (levels) of BAL
16) Confidence 0.15 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887148 Disease Relevance 0.57 Pain Relevance 0.08
The levels of cytokines in BAL fluid were assayed using Becton Dickinson (BD) Cytometric Bead Array™ (CBA; BD Biosciences, San Jose, CA) [10] according to manufacturer's instructions with an antibody (PharMoingen, San Diego, CA) against one of the five cytokines (Human Inflammation Kit: IL-8, IL-1?
Positive_regulation (cytokines) of Gene_expression (fluid) of BAL associated with inflammation and cytokine
17) Confidence 0.04 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 0.09 Pain Relevance 0.19
Interestingly, our findings suggest that airway inflammation may occur even in the absence of colonization as demonstrated by the significant increase in levels of the different inflammatory mediators between patients with negative BAL cultures and control subjects (Table 3).
Positive_regulation (increase) of Neg (negative) Gene_expression (cultures) of BAL associated with inflammatory mediators and inflammation
18) Confidence 0.04 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 1.20 Pain Relevance 0.23
Measurement of the BAL cytokines
Positive_regulation (Measurement) of Gene_expression (cytokines) of BAL associated with cytokine
19) Confidence 0.04 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 0.08 Pain Relevance 0.18
Concomitantly with the increase in BAL lymphocytes, blood CD4+ cells doubled in their proliferative capacity to PPD or Mtb culture filtrate protein stimulation (data not shown) at the 4 week time point in both immunoadjunctive rIFN-?
Positive_regulation (increase) of Gene_expression (lymphocytes) of BAL in blood associated with mycobacterial infection
20) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737621 Disease Relevance 0.94 Pain Relevance 0.11

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