INT23246

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Context Info
Confidence 0.64
First Reported 1982
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 37
Total Number 40
Disease Relevance 36.79
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB4) signal transduction (HLA-DRB4) Golgi apparatus (HLA-DRB4)
endoplasmic reticulum (HLA-DRB4) plasma membrane (HLA-DRB4)
Anatomy Link Frequency
T cell 4
leucocyte 2
Macrophages 1
blood 1
synovium 1
HLA-DRB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 170 99.92 Very High Very High Very High
Chronic pancreatitis 2 99.46 Very High Very High Very High
Arthritis 637 99.40 Very High Very High Very High
spinal inflammation 24 99.36 Very High Very High Very High
Inflammation 254 95.64 Very High Very High Very High
cytokine 108 93.24 High High
backache 4 88.32 High High
fibrosis 295 87.52 High High
abdominal pain 10 87.36 High High
Nerve growth factor 6 82.68 Quite High
Disease Link Frequency Relevance Heat
Death 155 100.00 Very High Very High Very High
Disease 384 99.98 Very High Very High Very High
Rheumatoid Arthritis 457 99.92 Very High Very High Very High
Uveitis 12 99.92 Very High Very High Very High
Pemphigoid 60 99.76 Very High Very High Very High
Apoptosis 341 99.70 Very High Very High Very High
Ductal Carcinoma 5 99.48 Very High Very High Very High
Pancreatitis 70 99.46 Very High Very High Very High
Low Back Pain 29 99.36 Very High Very High Very High
Cancer 339 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is the first study that shows that intervertebral disk cells express TRAIL, DR4 and DR5, which correlate to the degenerative state of the disk.
Gene_expression (express) of DR4
1) Confidence 0.64 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.35 Pain Relevance 0.04
Isolated disk cells were analyzed by flow cytometry for Fas, FasL, TRAIL, DR4 and DR5 expression.
Spec (analyzed) Gene_expression (expression) of DR4
2) Confidence 0.64 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.74 Pain Relevance 0.10
Intervertebral disks from 28 donors (age 12-70 years) suffering from scoliosis, vertebrae fracture or disk degeneration were scored histologically for degeneration and analyzed for gene expression of FasL/Fas, TRAIL/DR4, TNF-alpha/TNFR1 and caspase 8.
Spec (analyzed) Gene_expression (expression) of DR4 in vertebrae associated with scoliosis
3) Confidence 0.64 Published 2009 Journal Mod. Pathol. Section Abstract Doc Link 19305384 Disease Relevance 0.82 Pain Relevance 0.12
Patients with severe disease frequently express DR4 molecules that share an epitope in the third hypervariable region of the ?
Gene_expression (express) of DR4 associated with disease
4) Confidence 0.58 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175027 Disease Relevance 0.65 Pain Relevance 0.32
Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks.
Gene_expression (Expression) of DR4 associated with death
5) Confidence 0.56 Published 2009 Journal Mod. Pathol. Section Title Doc Link 19305384 Disease Relevance 0.79 Pain Relevance 0.13
Thus, TSP1, CASP8, HIC1, DcR1, DcR2 and DR4 and RASSF1 were methylated frequently in both tumour types (Astuti et al. 2001c, Margetts et al. 2005).
Gene_expression (methylated) of DR4 associated with cancer
6) Confidence 0.55 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.44 Pain Relevance 0.06
Neg (absent) Gene_expression (nt. Th) of DR4
7) Confidence 0.48 Published 1990 Journal Nephron Section Title Doc Link 2404214 Disease Relevance 1.77 Pain Relevance 0.09
Effects of laparoscopic and conventional (open) cholecystectomy on human leukocyte antigen-DR expression in peripheral blood monocytes: correlations with immunologic status.
Gene_expression (expression) of leukocyte antigen-DR in blood
8) Confidence 0.48 Published 1999 Journal World J Surg Section Title Doc Link 9841758 Disease Relevance 0.12 Pain Relevance 0.06
Cell sensitivity to TRAIL can be affected by TRAIL-receptor expression at the cell membrane, DR4/DR5 ratio and functionality of TRAIL-receptors.
Gene_expression (expression) of DR4
9) Confidence 0.47 Published 2004 Journal Drug Resist. Updat. Section Abstract Doc Link 15790545 Disease Relevance 1.12 Pain Relevance 0.06
Intriguingly, only the CD8+ T cell associated DR4, DcR1 and DcR2 expression levels correlated with DAS28 scores in patients with RA, implying that altered TRAIL receptor profiles on CD8+ T cell subsets rather than on CD4+ T cells is more important in terms of disease severity.


Gene_expression (expression) of DR4 in T cell associated with disease and arthritis
10) Confidence 0.32 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.98 Pain Relevance 0.37
In patients with invasive ductal carcinoma, however, high levels of DR4 expression are positively correlated with tumor grade and with poor prognosis [37].
Gene_expression (expression) of DR4 associated with ductal carcinoma and cancer
11) Confidence 0.32 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.55 Pain Relevance 0.22
Using a Spearman Rho correlation test to evaluate correlations between expression of TRAIL and TRAIL receptors on CD4+ T cells in RA patients, we found increased DR4 expression was correlated with an increase in both DR5 and TRAIL (Table 1).
Gene_expression (expression) of DR4 in T cells associated with arthritis
12) Confidence 0.32 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.74 Pain Relevance 0.33
CD8+ T cell associated DR4, DcR1 and DcR2 expression levels correlated with DAS28 scores in RA patients
Gene_expression (expression) of DR4 in T cell associated with arthritis
13) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.83 Pain Relevance 0.29
Interestingly only CD8+ T cell associated (Figure 4) but not CD4+ T cell associated (data not shown) DR4, DcR1 and DcR2 expression levels correlated with DAS28 scores in RA patients.


Gene_expression (expression) of DR4 in T cell associated with arthritis
14) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.84 Pain Relevance 0.30
Interestingly, the MHC class II antigen DR alpha was also found over-expressed in many types of cancers.
Gene_expression (expressed) of MHC class II antigen DR alpha associated with cancer
15) Confidence 0.22 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0.19 Pain Relevance 0
The microarray gene expression analysis of these cells indicates that the cells are negative for the hematopoietic markers CD34, CD49c, CD49d, CD62e, CD62p, CD106, CD117, CD133, CD235a, HLA-DRB4, HLA-DRB4 and HAS1, and positive for the mesenchymal markers CD13, CD29, CD44, CD49a/b, CD49e, CD73, CD105 and vimentin [18], supporting their USSCs/MSC origin.
Neg (negative) Gene_expression (negative) of HLA-DRB4
16) Confidence 0.20 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
The microarray gene expression analysis of these cells indicates that the cells are negative for the hematopoietic markers CD34, CD49c, CD49d, CD62e, CD62p, CD106, CD117, CD133, CD235a, HLA-DRB4, HLA-DRB4 and HAS1, and positive for the mesenchymal markers CD13, CD29, CD44, CD49a/b, CD49e, CD73, CD105 and vimentin [18], supporting their USSCs/MSC origin.
Neg (negative) Gene_expression (negative) of HLA-DRB4
17) Confidence 0.20 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956109 Disease Relevance 0 Pain Relevance 0
Macrophages did not inhibit the expression of DR4 or DR5, or modulate the levels of decoy receptors DcR1 or DcR2 in HCT116/Hke-3 cells (Figure S1), suggesting that they do not modulate the responsiveness to TRAIL through regulation of TRAIL receptors.
Gene_expression (expression) of DR4 in Macrophages
18) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.84 Pain Relevance 0.05
Susceptibility to PF has been correlated with the presence of DR4, DR14 and DR1 alleles; however, in contrast to PV, no single DR4 or DR14 allele was shown to be associated with the disease.

• In an immunogenetic study of patients with autoimmune pancreatitis, a significant increase in DR4 was found.

Gene_expression (presence) of DR4 associated with pancreatitis, pemphigoid and disease
19) Confidence 0.18 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.16 Pain Relevance 0.03
Susceptibility to PF has been correlated with the presence of DR4, DR14 and DR1 alleles; however, in contrast to PV, no single DR4 or DR14 allele was shown to be associated with the disease.

• In an immunogenetic study of patients with autoimmune pancreatitis, a significant increase in DR4 was found.

Gene_expression (allele) of DR14 associated with pancreatitis, pemphigoid and disease
20) Confidence 0.18 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.11 Pain Relevance 0.04

General Comments

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