INT232473

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Context Info
Confidence 0.69
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.35
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 180 100.00 Very High Very High Very High
Nav1.7 170 100.00 Very High Very High Very High
pulpitis 14 99.52 Very High Very High Very High
IPN 4 94.28 High High
sodium channel 34 64.16 Quite High
Acute pain 10 62.84 Quite High
Demyelination 10 56.56 Quite High
unmyelinated 14 54.24 Quite High
Inflammation 34 48.16 Quite Low
nociceptor 8 16.64 Low Low
Disease Link Frequency Relevance Heat
Pain 100 99.52 Very High Very High Very High
Pulpitis 14 99.32 Very High Very High Very High
Hyperalgesia 8 98.60 Very High Very High Very High
Inflammatory Pain 4 94.28 High High
Disease 6 65.84 Quite High
Demyelinating Disease 22 56.56 Quite High
INFLAMMATION 34 48.16 Quite Low
Neuropathic Pain 22 5.00 Very Low Very Low Very Low
Toothache 12 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, these results identify the increased association of Nav1.7 at both typical and atypical nodal sites and an increased occurrence of atypical nodal forms within painful samples.


Positive_regulation (increased) of Nav1 Binding (association) of associated with pain and nav1.7
1) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.89
The increased incidence of atypical nodal forms seen in our painful samples and the association of Nav1.7 with these atypical nodal forms provides evidence for the remodeling of NaChs at demyelinated sites as a pulpal pain mechanism.
Positive_regulation (increased) of Nav1 Binding (association) of associated with pain and nav1.7
2) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 1.35 Pain Relevance 1.42

General Comments

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