INT232494

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.50
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RANGAP1) signal transduction (RANGAP1) chromosome (RANGAP1)
cytoskeleton (RANGAP1) nucleus (RANGAP1) cytoplasm (RANGAP1)
Anatomy Link Frequency
cardiac muscle 1
erythrocyte 1
skeletal muscle 1
RANGAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 84 100.00 Very High Very High Very High
potassium channel 16 86.12 High High
Migraine 31 50.00 Quite Low
tetrodotoxin 16 27.52 Quite Low
Potency 4 25.20 Quite Low
sodium channel 12 23.84 Low Low
headache 3 21.52 Low Low
adenocard 8 5.00 Very Low Very Low Very Low
vagus nerve 4 5.00 Very Low Very Low Very Low
ergotamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 84 100.00 Very High Very High Very High
Hypoxia 44 100.00 Very High Very High Very High
Stress 4 86.40 High High
Pheochromocytoma 4 68.72 Quite High
Epilepsy 56 67.28 Quite High
Migraine Disorders 25 50.00 Quite Low
Migraine With Aura 4 27.56 Quite Low
Headache 2 21.52 Low Low
Injury 4 8.00 Low Low
Cancer 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since secondary waves run into partly refractory tissue, susceptibility to SD is decreased.
Localization (decreased) of susceptibility to SD associated with depression
1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659426 Disease Relevance 0.82 Pain Relevance 0.35
There is little doubt that mechanical distortion of the whole cell membrane can lead to the release of ATP into the immediate environment.
Localization (release) of mechanical distortion
2) Confidence 0.03 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2377322 Disease Relevance 0.38 Pain Relevance 0.14
In the cases of skeletal muscle, cardiac muscle, and erythrocyte some specific circumstances leading to ATP release, e.g. membrane depolarization, hypoxia, and mechanical distortion [25], should be addressed further.
Localization (release) of mechanical distortion in skeletal muscle associated with hypoxia
3) Confidence 0.03 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2377322 Disease Relevance 0.10 Pain Relevance 0
In the cases of skeletal muscle, cardiac muscle, and erythrocyte some specific circumstances leading to ATP release, e.g. membrane depolarization, hypoxia, and mechanical distortion [25], should be addressed further.
Localization (release) of mechanical distortion in cardiac muscle associated with hypoxia
4) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2377322 Disease Relevance 0.10 Pain Relevance 0
In the cases of skeletal muscle, cardiac muscle, and erythrocyte some specific circumstances leading to ATP release, e.g. membrane depolarization, hypoxia, and mechanical distortion [25], should be addressed further.
Localization (release) of mechanical distortion in erythrocyte associated with hypoxia
5) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2377322 Disease Relevance 0.10 Pain Relevance 0

General Comments

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