INT232495

Context Info Confidence 0.06 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.64 Pain Relevance 0.06

mitochondrion (VDAC1) plasma membrane (VDAC1) transmembrane transport (VDAC1)

Anatomy Link Frequency skeletal muscle 1 VDAC1 (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 2 63.44 tetrodotoxin 8 5.00 potassium channel 8 5.00 sodium channel 6 5.00 adenocard 4 5.00 ischemia 2 5.00 Neurotransmitter 2 5.00 agonist 2 5.00 vagus nerve 2 5.00 ergotamine 2 5.00

Disease Link Frequency Relevance Heat Hypoxia 22 83.76 Cystic Fibrosis 2 63.44 Increased Venous Pressure Under Development 4 63.36 Pressure Volume 2 Under Development 4 60.24 Shock 2 58.96 Stress 2 18.04 Cancer 14 15.92 Aging 10 5.00 Apoptosis 6 5.00 Weight Loss 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

VDAC is present in a multitude of tissue types, including human skeletal muscle [51] (Table 1).

Gene_expression (present) of VDAC in skeletal muscle

1) Confidence 0.06 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2377322 Disease Relevance 0.32 Pain Relevance 0.03

Thinnes et al. [60] have identified a voltage–dependent anion channel (VDAC, “porin”) which acts as a conduit for newly synthesized ATP in and out of the mitochondrion.

Gene_expression (synthesized) of VDAC

2) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2377322 Disease Relevance 0.32 Pain Relevance 0.03

General Comments

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