INT232504

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.89
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CD34) cell proliferation (CD34) signal transduction (CD34)
extracellular region (CD34) cell adhesion (CD34) cell motility (CD34)
Anatomy Link Frequency
bone marrow 2
stem cells 2
CD34 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 16 85.84 High High
Inflammation 22 68.32 Quite High
Arthritis 28 62.20 Quite High
Multiple sclerosis 31 33.88 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Dystrophy 70 94.80 High High
Peripheral Arterial Disease 51 93.64 High High
Rheumatoid Arthritis 16 85.84 High High
Obesity 28 72.52 Quite High
INFLAMMATION 20 68.32 Quite High
Arthritis 29 62.20 Quite High
Disease Progression 8 39.52 Quite Low
Disease 23 35.56 Quite Low
Multiple Sclerosis 37 33.88 Quite Low
Death 6 29.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Linear regression analysis showed a significant negative correlation between age and CD133+CXCR4+CD34- levels (r2?
Negative_regulation (correlation) of Gene_expression (levels) of CD34
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.54 Pain Relevance 0
Unexpectedly, the expression of CD34 was present in the majority of cultures, albeit that the signal was not as strong as for the markers CD73, CD105, and CD90.
Negative_regulation (present) of Gene_expression (expression) of CD34
2) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.41 Pain Relevance 0.20
Subsequent to the initial description, the same group reported after in vitro expansion the SVF derived cells had surface marker expression similar to bone marrow derived MSC, comprising of positive for CD29, CD44, CD71, CD90, CD105/SH2, and SH3 and lacking CD31, CD34, and CD45 expression [24].
Negative_regulation (lacking) of Gene_expression (expression) of CD34 in bone marrow
3) Confidence 0.25 Published 2009 Journal J Transl Med Section Body Doc Link PMC2679713 Disease Relevance 0.31 Pain Relevance 0.03
The lack of CD34 and CD56 expression suggested that none of the clonal cell lines was derived from haematopoetic, neural, or myogenic progenitors or stem cells.


Negative_regulation (lack) of Gene_expression (expression) of CD34 in stem cells
4) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575620 Disease Relevance 0.63 Pain Relevance 0

General Comments

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