INT232506

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.25
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PROM1) cilium (PROM1)
Anatomy Link Frequency
endothelial cells 2
superior 2
stem cells 2
neural 2
PROM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 15 90.88 High High
Demyelination 3 89.68 High High
Spinal cord 17 83.64 Quite High
cytokine 26 55.60 Quite High
cerebral cortex 1 51.84 Quite High
ischemia 1 48.88 Quite Low
Inflammation 14 48.08 Quite Low
palliative 2 46.92 Quite Low
midbrain 4 46.40 Quite Low
Dopamine 5 45.68 Quite Low
Disease Link Frequency Relevance Heat
Muscular Dystrophy 70 99.84 Very High Very High Very High
Cancer 120 96.12 Very High Very High Very High
Spinal Cord Injury 70 93.08 High High
Squamous Cell Carcinoma 8 91.64 High High
Demyelinating Disease 3 89.68 High High
Injury 53 88.92 High High
Paralysis 3 85.80 High High
Cardiovascular Disease 2 80.40 Quite High
Disease 18 79.08 Quite High
Adhesions 8 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the prognostic significance of the histological diagnosis strongly depends on the experience of the respective neuropathologist, analysis of both available data sets revealed that Nestin and CD133 expression was superior in predicting the patient's survival.
Positive_regulation (superior) of Gene_expression (expression) of CD133 in superior
1) Confidence 0.50 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2633002 Disease Relevance 0.47 Pain Relevance 0.05
The specific roles of these cells are uncertain; however it is possible that these cells may differentiate into endothelial cells, since a previous study showed that a subset of CD34-positive cells express AC133 as a true functional marker of endothelial progenitor cells.21
Positive_regulation (subset) of Gene_expression (express) of AC133 in endothelial cells
2) Confidence 0.32 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628011 Disease Relevance 0.14 Pain Relevance 0.03
The levels of CD133+CXCR4+CD34- stem cells were significantly higher in DMD patients compared to healthy controls (mean±standard deviation: 17.38±1.38 vs. 11.0±1.70; P?
Positive_regulation (higher) of Gene_expression (levels) of CD133 in stem cells associated with muscular dystrophy
3) Confidence 0.30 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2377332 Disease Relevance 0.82 Pain Relevance 0
Human neural stem cells (hCNS-SCns) were prospectively isolated based on fluorescence-activated cell sorting for a CD133+ and CD24?
Positive_regulation (activated) of Gene_expression (cell) of CD133 in neural
4) Confidence 0.13 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923623 Disease Relevance 1.01 Pain Relevance 0.16
UCLA-OSCCs were found to have higher surface expression of B7H1 and EGF-R and moderate expression of CD44 and no surface expression of CD133 whereas UCLA-OSCSCs expressed no or very low expression of B7H1, EGF-R and increased expression of CD133 and CD44bright (please see Figure S1).
Positive_regulation (have) of Neg (no) Gene_expression (expression) of CD133
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.45 Pain Relevance 0
Fetal mouse NSCs prospectively isolated by prominin expression are six fold enriched for Hes3 expression (6.42±1.9, n?
Positive_regulation (by) of Gene_expression (expression) of prominin
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.36 Pain Relevance 0.11

General Comments

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