INT232538

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Context Info
Confidence 0.77
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 23
Disease Relevance 12.35
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FAM5C) cytoplasm (FAM5C)
Anatomy Link Frequency
aorta 6
smooth muscle cells 4
artery 2
brain 2
pituitary 1
FAM5C (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 161 97.60 Very High Very High Very High
Angina 92 39.76 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 1426 100.00 Very High Very High Very High
Metabolic Syndrome 184 100.00 Very High Very High Very High
Pituitary Cancer 46 99.60 Very High Very High Very High
Aging 138 99.20 Very High Very High Very High
Atherosclerotic Plaque 92 99.04 Very High Very High Very High
Acute Coronary Syndrome 736 98.88 Very High Very High Very High
INFLAMMATION 161 97.60 Very High Very High Very High
Coronary Artery Disease 874 94.64 High High
Atherosclerosis 69 93.24 High High
Cancer 46 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine if FAM5C expression was specific to the brain and arteries, we assayed expression of FAM5C in 20 human tissues and found that it is expressed in many different tissue types at varying levels (Additional files, Figure 2).
Spec (determine) Gene_expression (expression) of FAM5C in brain
1) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.26 Pain Relevance 0
Since the T allele is protective in our sample (allelic odds ratio, 0.609 in CATHGEN, Table 2) and carriers of the T allele show decreased FAM5C gene expression in aorta, higher expression of FAM5C in the cells that make up the artery may be related to increased risk of MI.
Gene_expression (expression) of FAM5C in artery associated with myocardial infarction
2) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.26 Pain Relevance 0
FAM5C is expressed in proliferating human aortic smooth muscle cells and expression changes with passage
Gene_expression (expressed) of FAM5C in smooth muscle cells
3) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.25 Pain Relevance 0
Reverse transcriptase PCR (RT-PCR) identified FAM5C expression in both endothelial and aortic smooth muscle cells (Figure 5A, lanes 2, 3, and 4).
Gene_expression (expression) of FAM5C in smooth muscle cells
4) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.20 Pain Relevance 0
Given that FAM5C is expressed in human aorta, we sought to determine if FAM5C is expressed in smooth muscle and endothelial cells, the primary constituents of the human aorta.
Gene_expression (expressed) of FAM5C in aorta
5) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.23 Pain Relevance 0
To begin to address the functional role of FAM5C in MI, we observed that FAM5C is expressed in the human aorta and that its transcript levels decrease with increasing passage of AoSMC, suggesting that the level of gene expression may play a role in proliferation and senescence of this cell type.
Gene_expression (expressed) of FAM5C in aorta associated with aging and myocardial infarction
6) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.80 Pain Relevance 0
We measured the level of FAM5C expression in triplicate during each passage (passage 8 RNA was depleted) using real time RT-PCR.
Gene_expression (expression) of FAM5C
7) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.56 Pain Relevance 0
In order to determine if FAM5C expression was specific to the brain and arteries, we assayed expression of FAM5C in 20 human tissues and found that it is expressed in many different tissue types at varying levels (Additional files, Figure 2).
Gene_expression (expression) of FAM5C in brain
8) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.26 Pain Relevance 0
Given that FAM5C is expressed in human aorta, we sought to determine if FAM5C is expressed in smooth muscle and endothelial cells, the primary constituents of the human aorta.
Gene_expression (expressed) of FAM5C in aorta
9) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.23 Pain Relevance 0
We genotyped a set of aorta samples that we had previously collected for expression analysis [33] and we found that the inheritance of the T allele of rs10920501 is significantly associated with a reduction in the expression of FAM5C in aorta (Figure 4) (p = 0.03 in generalized model; p = 0.02 in mixed regression model to account for repeated measures).
Gene_expression (expression) of FAM5C in aorta
10) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.22 Pain Relevance 0
Since the T allele is protective in our sample (allelic odds ratio, 0.609 in CATHGEN, Table 2) and carriers of the T allele show decreased FAM5C gene expression in aorta, higher expression of FAM5C in the cells that make up the artery may be related to increased risk of MI.
Gene_expression (expression) of FAM5C gene in artery associated with myocardial infarction
11) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.26 Pain Relevance 0
We analyzed cis effects of FAM5C variants on FAM5C expression using the Affymetrix tag 34442_at, representing the 3' end of FAM5C.
Gene_expression (expression) of FAM5C
12) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.18 Pain Relevance 0
FAM5C allele specific gene expression
Gene_expression (expression) of FAM5C
13) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.14 Pain Relevance 0
We noted that the expression levels of FAM5C appeared to vary with AoSMC passage (compare p.5 and p.8 AoSMC RT-PCR Figure 5 and Additional files, Figure 2) and therefore hypothesized that FAM5C levels may change with proliferative capacity and cellular senescence.
Gene_expression (expression) of FAM5C associated with aging
14) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.35 Pain Relevance 0
We show that polymorphisms in FAM5C are associated with MI in two independent samples and that the SNP, which partially accounts for the linkage in our GENECARD ACS peak, is also significantly associated with changes in FAM5C gene expression in the human aorta.
Gene_expression (expression) of FAM5C gene in aorta associated with acute coronary syndrome and myocardial infarction
15) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.81 Pain Relevance 0
Two SNPs, rs2239816 and rs1891586, reside within genes, chromosome 1 open reading frame 9 protein (C1orf9) and FAM5C, and the third within an intergenic region (rs1324713).
Gene_expression (reside) of FAM5C
16) Confidence 0.67 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.75 Pain Relevance 0
FAM5C was originally identified in the mouse brain as a gene that is induced by bone morphogenic protein and retinoic acid signaling (BRINP3 gene) [51] and has recently been shown to be over-expressed in human pituitary tumors [24].
Gene_expression (expressed) of FAM5C in pituitary associated with pituitary cancer
17) Confidence 0.67 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.78 Pain Relevance 0
The relationship between MCP-1 levels, metabolic syndrome, MI, and FAM5C still remains to be defined.
Gene_expression (levels) of FAM5C associated with metabolic syndrome and myocardial infarction
18) Confidence 0.67 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 1.49 Pain Relevance 0.13
Last, we observed that levels of FAM5C change with passage in AoSMC, implying that genetic variation in the gene might be involved in AoSMC cellular processes involved in the formation of unstable atherosclerotic plaque leading to MI.
Gene_expression (change) of FAM5C in plaque associated with atherosclerotic plaque and myocardial infarction
19) Confidence 0.67 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.56 Pain Relevance 0
We found that FAM5C levels decrease as cells age in culture (Figure 5B).


Gene_expression (levels) of FAM5C
20) Confidence 0.67 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2383879 Disease Relevance 0.64 Pain Relevance 0

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