INT23254

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Context Info
Confidence 0.65
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 3.01
Pain Relevance 11.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) extracellular region (Npy)
Anatomy Link Frequency
vas deferens 4
hypothalamus 4
neurons 4
stage 5 2
EPI 2
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 78 100.00 Very High Very High Very High
Dopamine 12 100.00 Very High Very High Very High
Cannabinoid 33 99.98 Very High Very High Very High
narcan 39 99.86 Very High Very High Very High
Desipramine 17 99.84 Very High Very High Very High
bradykinin 9 99.80 Very High Very High Very High
Analgesic 3 99.74 Very High Very High Very High
antagonist 38 99.72 Very High Very High Very High
Opioid 11 99.62 Very High Very High Very High
Cannabinoid receptor 3 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 8 99.76 Very High Very High Very High
Diabetes Mellitus 3 99.64 Very High Very High Very High
Aids-related Complex 8 98.40 Very High Very High Very High
Myalgia 1 98.04 Very High Very High Very High
Neuropathic Pain 3 96.28 Very High Very High Very High
Hyperalgesia 1 95.88 Very High Very High Very High
Shock 5 94.80 High High
Hyperphagia 1 91.92 High High
Injury 2 86.64 High High
Disease 6 84.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to evoking the release of norepinephrine (NE), tyramine induced a dose-dependent increase of NPY-LI secretion which was insensitive to tetrodotoxin and was not affected by the removal of calcium ions from the bathing medium.
Positive_regulation (induced) of Localization (secretion) of NPY associated with tetrodotoxin
1) Confidence 0.65 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3595714 Disease Relevance 0 Pain Relevance 0.33
Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).
Positive_regulation (induced) of Localization (release) of NPY associated with desipramine
2) Confidence 0.50 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3108675 Disease Relevance 0 Pain Relevance 0.27
Desipramine suppressed the NPY-LI release induced by tyramine apparently by the inhibition of the uptake of tyramine is suggested by the significant positive correlation between the reduction of 14C-tyramine uptake and the inhibition of NPY-LI release induced by desipramine (r = 0.946).
Positive_regulation (induced) of Localization (release) of NPY associated with desipramine
3) Confidence 0.50 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3108675 Disease Relevance 0 Pain Relevance 0.26
Scorpion toxin of Androctonus australis garzonii induces neuropeptide Y release via bradykinin stimulation in rat atria and kidneys.
Positive_regulation (induces) of Localization (release) of neuropeptide Y associated with neuropeptide and bradykinin
4) Confidence 0.49 Published 2009 Journal Peptides Section Title Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.52
Taken together, these findings suggest that more NPY release, following low-intensity electrical stimulation of the injured nerve, significantly induces c-Fos expression in the CTNs, which possibly provide the ascending thalamic transmission of neuropathic pain signals.
Positive_regulation (induces) of Localization (release) of NPY in CTNs associated with neuropathic pain and projection neuron
5) Confidence 0.49 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19456245 Disease Relevance 0.52 Pain Relevance 0.62
Release of neuropeptide Y (NPY) induced by tyramine in the isolated vas deferens of rat.
Positive_regulation (induced) of Localization (Release) of NPY in vas deferens associated with neuropeptide
6) Confidence 0.47 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 3108675 Disease Relevance 0 Pain Relevance 0.23
Therefore, we suggest that tyramine does induce the release of NPY from rat vas deferens, in addition to effecting NE secretion.
Positive_regulation (induce) of Localization (release) of NPY in vas deferens
7) Confidence 0.47 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3108675 Disease Relevance 0 Pain Relevance 0.25
Streptozotocin-induced diabetic rats also showed increased hypothalamic NPY release compared to controls.
Positive_regulation (increased) of Localization (release) of NPY associated with diabetes mellitus
8) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 7804826 Disease Relevance 0.27 Pain Relevance 0.08
AM251, a cannabinoid receptor antagonist, blocked the augmentation of NPY release elicited by AEA and CP55,940.
Positive_regulation (augmentation) of Localization (release) of NPY associated with cannabinoid receptor and antagonist
9) Confidence 0.47 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15949823 Disease Relevance 0 Pain Relevance 0.61
Combined, these findings demonstrate that cannabinoids augment NPY release in the hypothalamus and that this may be a potential mechanism behind the orexigenic activity of cannabinoids.
Positive_regulation (augment) of Localization (release) of NPY in hypothalamus associated with cannabinoid
10) Confidence 0.47 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15949823 Disease Relevance 0 Pain Relevance 0.60
Forty-eight hours after one single after-discharge and 1 month after the last stage 5 seizure, 50 mM KCl induced a significantly larger release of NPY in the stimulated and contralateral hippocampus (P < 0.01 and P < 0.05), although the effect was less than during kindling.
Positive_regulation (induced) of Localization (release) of NPY in stage 5 associated with convulsion and hippocampus
11) Confidence 0.47 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 8287196 Disease Relevance 0.25 Pain Relevance 0.30
We tested the hypothesis that a decrease in hypothalamic inhibitory opioid tone produced by naloxone (NAL) will activate neuropeptide-Y (NPY) neurosecretion in 17 beta-estradiol (E2)-primed ovariectomized (ovx) rats.
Positive_regulation (activate) of Localization (neurosecretion) of neuropeptide-Y associated with neuropeptide, narcan and opioid
12) Confidence 0.46 Published 1990 Journal Endocrinology Section Abstract Doc Link 2404749 Disease Relevance 0.05 Pain Relevance 0.44
Collectively, these results show that a decrease in opioid influence rapidly augments NPY gene expression in a subpopulation of neurons in the ARC, and support the hypothesis that a disinhibition from opioid influence acutely promotes NPY synthesis and release, which is necessary for phasic LH discharge in rats.
Positive_regulation (necessary) of Localization (release) of NPY in neurons associated with aids-related complex and opioid
13) Confidence 0.45 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.33 Pain Relevance 0.55
Collectively, these results show that a decrease in opioid influence rapidly augments NPY gene expression in a subpopulation of neurons in the ARC, and support the hypothesis that a disinhibition from opioid influence acutely promotes NPY synthesis and release, which is necessary for phasic LH discharge in rats.
Positive_regulation (promotes) of Localization (release) of NPY in neurons associated with aids-related complex and opioid
14) Confidence 0.45 Published 1996 Journal Endocrinology Section Abstract Doc Link 8536645 Disease Relevance 0.33 Pain Relevance 0.55
Incubation of INS-1 cells with various glucose concentrations did not modify NPY secretion; however, stimulation of adenylate cyclase by forskolin induced a dose- and time-dependent increase in NPY release in the medium.
Positive_regulation (increase) of Localization (release) of NPY
15) Confidence 0.45 Published 1993 Journal Endocrinology Section Abstract Doc Link 8396008 Disease Relevance 0.15 Pain Relevance 0.18
In addition to evoking the release of norepinephrine (NE), tyramine induced a dose-dependent increase of NPY-LI secretion which was insensitive to tetrodotoxin and was not affected by the removal of calcium ions from the bathing medium.
Positive_regulation (increase) of Localization (secretion) of NPY associated with tetrodotoxin
16) Confidence 0.44 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3595714 Disease Relevance 0 Pain Relevance 0.33
Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus.
Positive_regulation (augment) of Localization (release) of neuropeptide Y in hypothalamus associated with cannabinoid and neuropeptide
17) Confidence 0.41 Published 2005 Journal Neuropharmacology Section Title Doc Link 15949823 Disease Relevance 0 Pain Relevance 0.83
Twenty-five, 50 and 100 mM KCl induced a concentration-dependent release of NPY (P < 0.05 and P < 0.01 at 25 and 50-100 mM respectively) from slices of shams.
Positive_regulation (induced) of Localization (release) of NPY
18) Confidence 0.41 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 8287196 Disease Relevance 0.22 Pain Relevance 0.31
The results show that A. australis garzonii scorpion toxin stimulates NPY release from both rat atria and kidneys, and suggest that the toxin induces NPY release via BK stimulation through B2 receptors.
Positive_regulation (stimulates) of Localization (release) of NPY
19) Confidence 0.39 Published 2009 Journal Peptides Section Abstract Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.52
We showed that the scorpion toxin (10(-6)M) increased the NPY release from both atria (35%) and kidneys (40%).
Positive_regulation (increased) of Localization (release) of NPY
20) Confidence 0.39 Published 2009 Journal Peptides Section Abstract Doc Link 19433126 Disease Relevance 0 Pain Relevance 0.59

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