INT232550

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.96
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Erbb2) plasma membrane (Erbb2) nucleus (Erbb2)
kinase activity (Erbb2) cytoplasm (Erbb2)
Anatomy Link Frequency
A549 2
BT-474 2
Erbb2 (Mus musculus)
Pain Link Frequency Relevance Heat
positron emission tomography 35 83.00 Quite High
imagery 57 57.56 Quite High
agonist 8 11.60 Low Low
isoflurane 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 59 99.84 Very High Very High Very High
Cancer 426 99.44 Very High Very High Very High
Apoptosis 30 90.04 High High
Metastasis 9 86.56 High High
Lung Cancer 29 85.44 High High
Death 10 84.20 Quite High
Disease Progression 5 81.20 Quite High
Pressure And Volume Under Development 40 75.48 Quite High
Hyperplasia 5 73.40 Quite High
Glioblastoma 7 73.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The promoter of the HER-2 gene also contains an oestrogen response element which suppresses HER-2 expression on response to oestrogen and is overexpressed with tamoxifen [34,35].
Negative_regulation (suppresses) of Gene_expression (expression) of HER-2
1) Confidence 0.43 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2383915 Disease Relevance 0.44 Pain Relevance 0
By 72 h radiotracer uptake (73.64±12.17%ID/g) and Western blot analysis demonstrated that HER2/neu expression recovered to baseline levels.


Negative_regulation (recovered) of Gene_expression (expression) of HER2/neu
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2810330 Disease Relevance 0.14 Pain Relevance 0
Two main methods exist for the determination of HER2 gene amplification and protein expression in breast cancer specimens, fluorescence in situ hybridisation or FISH (direct or indirect) and IHC.
Negative_regulation (determination) of Gene_expression (expression) of HER2 gene associated with breast cancer
3) Confidence 0.42 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2383915 Disease Relevance 1.16 Pain Relevance 0
0.25 µM, decreased expression levels of Hsp90 client onco-proteins including HER2/neu, Akt and RAF1, compared to DMSO-treated controls.
Negative_regulation (decreased) of Gene_expression (expression) of HER2/neu
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.16 Pain Relevance 0
The approximate 3-fold decrease in BT-474 T/M ratios between the vehicle-treated and PU-H71 treated mice is consistent with the decrease in HER2/neu expression levels observed by in vivo Western blots (Figure 4).
Negative_regulation (decrease) of Gene_expression (expression) of HER2/neu in BT-474
5) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810330 Disease Relevance 0.65 Pain Relevance 0.03
We assessed the expression of p53 and Her2 in both original tumor tissues and cell lines.
Negative_regulation (assessed) of Gene_expression (expression) of Her2 associated with cancer
6) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.81 Pain Relevance 0
As expected, lapatinib reduced levels of p-EGFR, p-HER-2, and p-ERK1/2 in A549 cells.
Negative_regulation (reduced) of Gene_expression (levels) of p-HER-2 in A549
7) Confidence 0.33 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.43 Pain Relevance 0
Tumor tissues from both patients exhibited Her2 expression (Figure 2C and 2G), however the level of expression was stronger in the TOV-2223 tumor tissue (Figure 2G).
Negative_regulation (exhibited) of Gene_expression (expression) of Her2 associated with cancer
8) Confidence 0.30 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.81 Pain Relevance 0
Surface expression of HER-2 proteins was almost negative on both cell lines, while HER-3 was expressed only in the U138MG cell line.
Negative_regulation (negative) of Gene_expression (expression) of HER-2
9) Confidence 0.21 Published 2010 Journal Mol Imaging Biol Section Body Doc Link PMC2978890 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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